Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4518
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dc.contributor.authorAtalay, Erol Ömer-
dc.contributor.authorÜstel, E.-
dc.contributor.authorYildiz, S.-
dc.contributor.authorAtalay, Ayfer-
dc.date.accessioned2019-08-16T11:34:37Z
dc.date.available2019-08-16T11:34:37Z
dc.date.issued2006-
dc.identifier.issn0363-0269-
dc.identifier.urihttps://hdl.handle.net/11499/4518-
dc.identifier.urihttps://doi.org/10.1080/03630260600755807-
dc.description.abstractThe surface plasmon resonance (SPR) approach, being a relatively novel biophysical method, is used to detect many different targets by biomolecular interaction. The SPR system uses optical and evanescent wave phenomenon. This approach does not need any labels, such as enzymes or isotopes, and the monitored interactions are in real time. In DNA-DNA interaction, the SPR approach is Tm-independent. Here we report our preliminary results for the molecular detection of the Hb S (G A G ›G T G) mutation at codon 6 of the human ß-globin gene. Our preliminary results show that the SPR approach could be applied as an inexpensive and fast routine test system for the molecular diagnosis of abnormal hemoglobins (Hbs), especially in premarital screening programs. Copyright © Taylor & Francis Group, LLC.en_US
dc.language.isoenen_US
dc.relation.ispartofHemoglobinen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbnormal hemoglobin (Hb)en_US
dc.subjectHb Sen_US
dc.subjectMutation detectionen_US
dc.subjectSurface plasmon resonance (SPR)en_US
dc.subjectadenineen_US
dc.subjectglutamic aciden_US
dc.subjectguanineen_US
dc.subjecthemoglobin Sen_US
dc.subjecthemoglobin varianten_US
dc.subjectthymineen_US
dc.subjectvalineen_US
dc.subjectarticleen_US
dc.subjectcodonen_US
dc.subjectcontrolled studyen_US
dc.subjectcosten_US
dc.subjectdiagnostic valueen_US
dc.subjectgenetic analysisen_US
dc.subjectglobin geneen_US
dc.subjecthemoglobinopathyen_US
dc.subjecthumanen_US
dc.subjecthuman geneticsen_US
dc.subjectmedical examinationen_US
dc.subjectmutational analysisen_US
dc.subjectscreening testen_US
dc.subjectsurface plasmon resonanceen_US
dc.subjectGenetic Counselingen_US
dc.subjectGlobinsen_US
dc.subjectHemoglobin, Sickleen_US
dc.subjectHumansen_US
dc.subjectPoint Mutationen_US
dc.subjectPremarital Examinationsen_US
dc.subjectSurface Plasmon Resonanceen_US
dc.titleSurface plasmon resonance-based molecular detection of Hb S [ß6(A3)Glu›Val, GAG›GTG] at the gene levelen_US
dc.typeArticleen_US
dc.identifier.volume30en_US
dc.identifier.issue3en_US
dc.identifier.startpage385
dc.identifier.startpage385en_US
dc.identifier.endpage391en_US
dc.authorid0000-0001-6272-9380-
dc.authorid0000-0001-7987-9078-
dc.identifier.doi10.1080/03630260600755807-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid16840230en_US
dc.identifier.scopus2-s2.0-33746267905en_US
dc.identifier.wosWOS:000239075000006en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale_University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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