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https://hdl.handle.net/11499/4545
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Emrecan, B. | - |
dc.contributor.author | Tulukoglu, E. | - |
dc.contributor.author | Bozok, S. | - |
dc.contributor.author | Kestelli, M. | - |
dc.contributor.author | Önem, Gökhan. | - |
dc.contributor.author | Küpelioglu, A. | - |
dc.contributor.author | Yagdi, S. | - |
dc.date.accessioned | 2019-08-16T11:34:51Z | |
dc.date.available | 2019-08-16T11:34:51Z | |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0949-2321 | - |
dc.identifier.uri | https://hdl.handle.net/11499/4545 | - |
dc.description.abstract | Objective: In ischemia-reperfusion, Iloprost decreases neutrophil activation and aggregation besides inhibition of oxygen-free radical production. Pentoxifylline (Ptx) attenuates reperfusion-associated membrane injury and tissue edema, suppresses leukocyte adhesion and improves hindlimb blood flow during the reperfusion period. The primary hypothesis in this study was that Iloprost could present better protection than pentoxyfillin on renal ischemia-reperfusion in rabbit model. Materials and Methods: Forty rabbits were grouped into four. Iloprost was continuously infused starting half an hour before the reperfusion after 2 hours ischemia and during the 4 hours reperfusion period in Group 1 whereas the Group 2 was treated with pentoxyfillin. Group 3 was the control group which didn't receive any medication. Forth group was sham group. Renal tissues were histologically and biochemically evaluated. Results: The histologic scores were obtained according to presence of tubuler necrosis and atrophy, regenerative atypia, hydropic degeneration (Group 1 vs Group 3; p<0.001, Group 2 vs Group 3; p = 0.001, Group 1 vs Group 2; p = 0.331). Malondialdehyde levels of the medicated groups were 109 ± 11 nmol/gr tissue in Group 1, 119 ± 15 nmol/gr tissue in Group 2 and 132 ± 14 nmol/gr tissue in Group 3 (Group 1 vs Group 2; p = 0.130, Group 1 vs Group 3, p = 0.002, Group 2 vs Group 3; p = 0.045). Malondialdehyde levels and histologic scores of all of the groups were significantly different from the sham group. Conclusion: Iloprost and pentoxyfillin reduced renal ischemia-reperfusion injury in rabbit model. There was not a significant difference between these two medications. © I. Holzapfel Publishers 2006. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | European Journal of Medical Research | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Iloprost | en_US |
dc.subject | Ischemia-reperfusion injury | en_US |
dc.subject | Pentoxyfillin | en_US |
dc.subject | Rabbit kidney | en_US |
dc.subject | iloprost | en_US |
dc.subject | malonaldehyde | en_US |
dc.subject | pentoxifylline | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | article | en_US |
dc.subject | continuous infusion | en_US |
dc.subject | controlled study | en_US |
dc.subject | drug mechanism | en_US |
dc.subject | female | en_US |
dc.subject | histopathology | en_US |
dc.subject | hypothesis | en_US |
dc.subject | kidney ischemia | en_US |
dc.subject | kidney parenchyma | en_US |
dc.subject | kidney tubule necrosis | en_US |
dc.subject | male | en_US |
dc.subject | maximum permissible dose | en_US |
dc.subject | nonhuman | en_US |
dc.subject | rabbit | en_US |
dc.subject | renal protection | en_US |
dc.subject | reperfusion | en_US |
dc.subject | statistical significance | en_US |
dc.subject | Animals | en_US |
dc.subject | Disease Models, Animal | en_US |
dc.subject | Drug Therapy, Combination | en_US |
dc.subject | Female | en_US |
dc.subject | Kidney | en_US |
dc.subject | Kidney Cortex | en_US |
dc.subject | Kidney Tubules | en_US |
dc.subject | Lipid Peroxidation | en_US |
dc.subject | Male | en_US |
dc.subject | Malondialdehyde | en_US |
dc.subject | Pentoxifylline | en_US |
dc.subject | Platelet Aggregation Inhibitors | en_US |
dc.subject | Rabbits | en_US |
dc.subject | Reperfusion Injury | en_US |
dc.subject | Severity of Illness Index | en_US |
dc.subject | Treatment Outcome | en_US |
dc.subject | Vasodilator Agents | en_US |
dc.title | Effects of Iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 295 | |
dc.identifier.startpage | 295 | en_US |
dc.identifier.endpage | 299 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopus | 2-s2.0-33747240744 | en_US |
dc.identifier.wos | WOS:000239921600006 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale_University | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 13.01. Private Law | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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