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Title: | Effects of second generation tetracyclines on penicillin-epilepsy-induced hippocampal neuronal loss and motor incoordination in rats | Authors: | Yılmaz, İsmail. Adıgüzel, Esat. Akdoğan, Ilgaz. Kaya, Ertuğrul. Hatip-Al-Khatib, İzzettin. |
Keywords: | Doxycycline Hippocampus Minocycline Neuronal cell count Penicillin-epilepsy Rotarod doxycycline minocycline penicillin G tetracycline animal cell animal experiment animal model animal tissue article brain nerve cell cell count cell loss controlled study coordination disorder drug effect epilepsy hippocampus male motor coordination nonhuman rat rotarod test task performance Animals Ataxia Cell Count Epilepsy Male Neurons Neuroprotective Agents Penicillin G Rats Rotarod Performance Test |
Abstract: | Epileptic seizures cause pathological changes such as sclerosis and pyramidal neuronal loss in the hippocampus. Experimentally, epilepsy can be induced by application of various chemicals directly to the cerebral cortex. In this study, epilepsy was induced in rats by intracortical application of 500 IU penicillin G, and the effect of minocycline and doxycycline on the resulting motor incoordination (rotarod) and hippocampal neuronal loss in CA1, CA2 and CA3 fields (optical fractionator method) were investigated. The rotarod performance was reduced in the epilepsy group to 285.1 ± 6.9 s (P < 0.05 vs. sham-300 s). Minocycline and doxycycline increased this performance to 297.4 ± 1.0 s and 296.9 ± 1.2 s respectively. No significant difference was detected between minocycline and doxycycline. The present results also showed that the number of neurons (× 103) in the sham group was 150 ± 9. In the penicillin-epileptic rats, the number was decreased to 105 ± 7 (P < 0.01). Minocycline, but not doxycycline (125 ± 8), significantly increased the number to 131 ± 3 (P < 0.05). In conclusion, the second generation tetracycline minocycline decreased the loss of hippocampal neurons and motor incoordination in penicillin-epileptic rats. Minocycline could protect against a variety of neurological insults including epilepsy. © 2006 Elsevier Inc. All rights reserved. | URI: | https://hdl.handle.net/11499/4550 https://doi.org/10.1016/j.lfs.2006.02.027 |
ISSN: | 0024-3205 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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