Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4550
Title: Effects of second generation tetracyclines on penicillin-epilepsy-induced hippocampal neuronal loss and motor incoordination in rats
Authors: Yılmaz, İsmail.
Adıgüzel, Esat.
Akdoğan, Ilgaz.
Kaya, Ertuğrul.
Hatip-Al-Khatib, İzzettin.
Keywords: Doxycycline
Hippocampus
Minocycline
Neuronal cell count
Penicillin-epilepsy
Rotarod
doxycycline
minocycline
penicillin G
tetracycline
animal cell
animal experiment
animal model
animal tissue
article
brain nerve cell
cell count
cell loss
controlled study
coordination disorder
drug effect
epilepsy
hippocampus
male
motor coordination
nonhuman
rat
rotarod test
task performance
Animals
Ataxia
Cell Count
Epilepsy
Male
Neurons
Neuroprotective Agents
Penicillin G
Rats
Rotarod Performance Test
Abstract: Epileptic seizures cause pathological changes such as sclerosis and pyramidal neuronal loss in the hippocampus. Experimentally, epilepsy can be induced by application of various chemicals directly to the cerebral cortex. In this study, epilepsy was induced in rats by intracortical application of 500 IU penicillin G, and the effect of minocycline and doxycycline on the resulting motor incoordination (rotarod) and hippocampal neuronal loss in CA1, CA2 and CA3 fields (optical fractionator method) were investigated. The rotarod performance was reduced in the epilepsy group to 285.1 ± 6.9 s (P < 0.05 vs. sham-300 s). Minocycline and doxycycline increased this performance to 297.4 ± 1.0 s and 296.9 ± 1.2 s respectively. No significant difference was detected between minocycline and doxycycline. The present results also showed that the number of neurons (× 103) in the sham group was 150 ± 9. In the penicillin-epileptic rats, the number was decreased to 105 ± 7 (P < 0.01). Minocycline, but not doxycycline (125 ± 8), significantly increased the number to 131 ± 3 (P < 0.05). In conclusion, the second generation tetracycline minocycline decreased the loss of hippocampal neurons and motor incoordination in penicillin-epileptic rats. Minocycline could protect against a variety of neurological insults including epilepsy. © 2006 Elsevier Inc. All rights reserved.
URI: https://hdl.handle.net/11499/4550
https://doi.org/10.1016/j.lfs.2006.02.027
ISSN: 0024-3205
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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