Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4568
Title: Carotid intima-media thickness in coronary slow flow: Relationship with plasma homocysteine levels
Authors: Tanriverdi, Halil
Evrengul, H.
Tanriverdi, S.
Kuru, O.
Seleci, D.
Enli, Yaşar
Kaftan, Asuman
Keywords: Carotid atherosclerosis
Coronary slow flow
Homocysteine
Intima-media thickness
cyanocobalamin
folic acid
homocysteine
adult
amino acid blood level
amino acid metabolism
angina pectoris
angiocardiography
artery intima proliferation
artery wall
article
blood clot lysis
blood sampling
brain angiography
brain atherosclerosis
cardiovascular risk
carotid artery disease
carotid atherosclerosis
clinical article
controlled study
coronary artery blood flow
correlation analysis
disease marker
female
flowmeter
folic acid blood level
heart infarction
human
male
neuropathology
population research
priority journal
risk assessment
tunica media
vitamin blood level
Aged
Carotid Arteries
Carotid Artery Diseases
Case-Control Studies
Coronary Angiography
Coronary Arteriosclerosis
Coronary Circulation
Female
Folic Acid
Humans
Male
Middle Aged
Myocardial Infarction
Reference Values
Tunica Intima
Tunica Media
Abstract: BACKGROUND AND OBJECTIVE: Coronary slow-flow phenomenon is characterized by delayed opacification of coronary vessels in a normal coronary angiogram. Although clinical and pathological features have been previously described, the underlying pathophysiology has not been fully elucidated. Thus, it still remains to be determined whether either microvascular or epicardial diffuse atherosclerotic disease is related to slow flow. In this study, we aimed to determine the carotid artery intima-media thickness, which is a marker of atherosclerosis in patients with coronary slow flow, and its possible relationship with the total homocysteine level. METHOD: The study population consisted of 88 patients who underwent coronary angiography because of typical and quasi-typical symptoms of angina. Forty-four patients with angiographically proven coronary slow flow and 44 individuals with normal coronary flow pattern with similar risk profiles were enrolled in the study. Coronary flow patterns of the latter were determined by the thrombolysis in myocardial infarction frame count method. Intima-media thickness was measured by recording ultrasonographic images of both the left and the right common carotid artery with a 12-MHz linear array transducer. Plasma homocysteine, folate and B12 levels were measured from blood samples. RESULTS: Plasma homocysteine levels (µmol/l) and carotid intima-media thickness (mm) of patients with coronary slow flow were found to be significantly higher than that of controls (12.4±4.9 vs. 8.5±2.8, P=0.0001; 0.75±0.08 vs. 0.69±0.06, P=0.0001, respectively). The plasma folate level (ng/ml) was lower in coronary slow-flow patients than in controls (13.8±4.4 vs. 16.5±5.6, P=0.014). The plasma homocysteine level was significantly positively correlated with the mean thrombolysis in myocardial infarction frame count and intima-media thickness of the carotid artery in correlation analysis (r=0.58, P=0.0001; r=0.41, P=0.0001; respectively). CONCLUSION: Homocysteine levels and carotid intima-media thickness increased but folate levels decreased in patients with coronary slow flow. The present findings allow us to conclude that the possible disturbance in the metabolism of homocysteine in patients with coronary slow flow may have a role in the etiopathogenesis of this phenomenon by causing generalized atherosclerosis. © 2006 Lippincott Williams & Wilkins.
URI: https://hdl.handle.net/11499/4568
https://doi.org/10.1097/00019501-200606000-00002
ISSN: 0954-6928
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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