Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4574
Title: Sex chromosome aneuploidy rates in the somatic cells of infertile men
Authors: Düzcan, Füsun.
Aybek, Zafer.
Tepeli, E.
Caner, Vildan.
Çetin, Gökhan Ozan.
Aybek, Hülya.
Bağcı, Hüseyin.
Keywords: Aneuploidy
Hybridization in situ, fluorescence
Infertility, male
adult
aneuploidy
article
centromere
chromosome satellite association
clinical article
controlled study
fluorescence in situ hybridization
human
incidence
karyotyping
male
male infertility
mitosis
oligospermia
priority journal
sex chromosome aberration
somatic cell
spermatozoon count
testis size
X chromosome
Y chromosome
Adult
Chromosomes, Human, Y
Humans
Infertility, Male
Karyotyping
Male
Oligospermia
Sex Chromosome Aberrations
Abstract: OBJECTIVE: A large number of studies have shown that the prevalence of somatic chromosome abnormalities detectable with karyotyping is higher in infertile men. However, a normal somatic karyotype does not exclude the chance of having low level mosaicism. STUDY DESIGN: Eleven men with severe oligozoospermia and 10 healthy, fertile men were included in this study. All the patients had severe oligozoospermia with sperm counts ? 3,000,000/mL. All participants had normal physical findings and testicular volume. The probe for dual-color fluorescence in situ hybridization consisted of an alpha satellite sequence in the centromeric region of chromosome X (DXZ1) and satellite III DNA at the Yq12 region of chromosome Y (DYZ1). RESULTS: The sex chromosome aneuploidy rate was significantly higher in subjects than in controls (p<0.001). The median incidence of sex chromosome aneuploidy in the oligozoospermic group was 4.5% (range, 0.8-7.3%), while in the control group it was 0.7% (range, 0.2-1.2%). CONCLUSION: The incidence of aneuploidy in somatic cells is significantly greater in oligozoospermic men than in normal controls. That may suggest that chromosome instability is a result of altered genetic control during mitotic cell division. Our results demonstrate that men with oligozoospermia have an elevated risk for sex chromosome abnormalities in their somatic cells. © Journal of Reproductive Medicine®, Inc.
URI: https://hdl.handle.net/11499/4574
ISSN: 0024-7758
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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