Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46040
Title: Comparison of Radiochemical and Chemical Impurities in Liquid Wastes of Two Different Ge-68/Ga-68 Generators used in Nuclear Medicine PET Chemistry
Authors: Ugur, Ayse
Yaylali, Olga
Yuksel, Dogangun
Keywords: Gallium-68
Ge-68/Ga-68 generator
chemical impurity
GMP
Ge-68
Publisher: Galenos Yayincilik
Abstract: Objectives: Germanium-68/gallium-68 (Ge-68/Ga-68) generator eluate contains a number of metal cations that can compete with (GaCl3)-Ga-68, reducing specific radioactivity. The first step in peptide labeling with (GaCl3)-Ga-68 is to remove Ge-68 and several other metals with a long half-life. In this purification step, the elution residue that is passed through the cartridge is collected in glass waste bottles. Waste management is included in good production practices, and in particular, the activity of long half-life Ge-68 (270.95 days) and other toxic metal levels need to be examined. Our objective in this study is to determine the Ge-68 activity in liquid waste produced by the generation of Ga-68 and heavy metal concentrations from the generator column materials and to assess whether it can be disposed of as normal waste. Methods: Liquid wastes produced by passing the Ge-68/Ga-68 generator eluate of 2 different identities via PSH+ cartridge have been analyzed with the inductively coupled plasma mass spectrometry device in the advanced technology application and research center of our university. Results: The average of the Ge-68 radioactive pollution was estimated to be 0.142 ppm (mu g.mL(-1)) in the liquid waste analysis after passing through the PSH+ cartridge in the pre-elution in the GalluGEN brand generator. While there was no tin (Sn) impurity, it was determined that the average zinc (Zn) was 1.95 ppm (mu g.mL(-1)) and the average aluminum (Al) impurity was 10.95 ppm (mu g.mL(-1)). While no Ge-68 radioactive pollution was determined in the iThemba LABS brand generator, the average Sn was 0.098 ppm (mu g.mL(-1)), average Zn 48.6 ppm (mu g.mL(-1)), and average Al impurity 4.135 ppm (mu g.mL(-1)). Conclusion: All Ge-68/Ga-68 generators produced have their own certificates. Metallic contamination in the postmarking waste of Ge-68/Ga-68 generators can be different. It would be a safe method to keep these wastes in place until they are dumped into the sewage systems, given their half-lives in terms of long half-life radioactive metallic contamination.
URI: https://doi.org/10.4274/mirt.galenos.2020.58569
https://search.trdizin.gov.tr/yayin/detay/413102
https://hdl.handle.net/11499/46040
ISSN: 2146-1414
2147-1959
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
MIRT-30-34-En.pdf193.3 kBAdobe PDFView/Open
Show full item record



CORE Recommender

Page view(s)

60
checked on May 6, 2024

Download(s)

16
checked on May 6, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.