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https://hdl.handle.net/11499/46052
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gurses, Dolunay | - |
dc.contributor.author | Oguz, Merve | - |
dc.contributor.author | Yilmaz, Munevver | - |
dc.contributor.author | Aybek, Hulya | - |
dc.contributor.author | Akpinar, Funda | - |
dc.date.accessioned | 2023-01-09T21:08:27Z | - |
dc.date.available | 2023-01-09T21:08:27Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2148-5046 | - |
dc.identifier.issn | 1309-0283 | - |
dc.identifier.uri | https://doi.org/10.46497/ArchRheumatol.2021.8232 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/445762 | - |
dc.identifier.uri | https://hdl.handle.net/11499/46052 | - |
dc.description.abstract | Objectives: This study aims to investigate serum pentraxin 3 (PTX3) levels during acute episode of acute rheumatic fever (ARF) and their relationship with disease severity. Patients and methods: The prospective study was conducted between January 2015 and December 2018 and included 52 ARF patients (22 girls, 30 boys, mean age 10.7 +/- 2.1 years; range, 5 to 16 years) experiencing an acute episode and 22 healthy children (13 girls, 9 boys, mean age 10.3 +/- 3.8 years; range, 5 to 16 years). ARF patients were classified into three groups based on the clinical course: isolated arthritis (n=17), mild carditis (n=19), and moderate/severe carditis (n=16). Blood samples were collected from all patients before treatment and from the healthy children in the control group to measure PTX3 levels. PTX3 was measured using sandwich enzyme-linked immunosorbent assay method. Results: Plasma PTX3 levels were significantly higher in ARF group compared to the control group (4.7 +/- 5.2 and 1.2 +/- 1.7 ng/mL, p<0.001). Subgroup analysis of serum PTX3 levels in ARF patients with isolated arthritis, mild carditis, and moderate/severe carditis (3.2 +/- 3.1 ng/mL, 4.3 +/- 5 ng/mL, and 6.7 +/- 6.6 ng/mL, respectively) showed that serum PTX3 was significantly higher in the moderate/severe carditis group compared to the other groups (p<0.05). Analysis of echocardiographic data showed that serum PTX3 was positively correlated with left ventricular end-diastolic diameter, left atrial diameters, and mitral A velocity and negatively correlated with E/A ratio (p<0.05; r=0.231, 0.402, 0.562, -0.586, respectively). Conclusion: High PTX3 level during an acute episode of ARF may help predict the clinical course and the severity of accompanying carditis. However, prospective studies with larger sample sizes are needed. | en_US |
dc.description.sponsorship | Pamukkale University Research Fund [2018HZP047] | en_US |
dc.description.sponsorship | This research has been supported by Pamukkale University Research Fund (Number 2018HZP047). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Turkish League Against Rheumatism | en_US |
dc.relation.ispartof | Archives Of Rheumatology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acute rheumatic fever | en_US |
dc.subject | child | en_US |
dc.subject | pentraxin 3 | en_US |
dc.subject | Ptx3 | en_US |
dc.subject | Echocardiography | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Criteria | en_US |
dc.subject | Tissue | en_US |
dc.title | Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 233 | en_US |
dc.identifier.endpage | 243 | en_US |
dc.authorid | OGUZ, Merve/0000-0002-7211-327X | - |
dc.identifier.doi | 10.46497/ArchRheumatol.2021.8232 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 6603227515 | - |
dc.authorscopusid | 57205022857 | - |
dc.authorscopusid | 57210550564 | - |
dc.authorscopusid | 10639634200 | - |
dc.authorscopusid | 56399197800 | - |
dc.authorwosid | OĞUZ, MERVE/AAZ-5349-2021 | - |
dc.authorwosid | Akpinar, Funda/GSE-3820-2022 | - |
dc.identifier.pmid | 34527928 | en_US |
dc.identifier.scopus | 2-s2.0-85107838984 | en_US |
dc.identifier.trdizinid | 445762 | en_US |
dc.identifier.wos | WOS:000657513700010 | en_US |
dc.identifier.scopusquality | Q4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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2021-36-2-233-243-eng.pdf | 218.48 kB | Adobe PDF | View/Open |
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