Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46081
Title: Evaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter study
Authors: Yanik Yalcin, Tugba
Azap, Ozlem
Kose, Adem
Bayindir, Yasar
Saricaoglu, Elif Mukime
Cinar, Gule
Uygun Kizmaz, Yesim
KurSun, Ebru
Aliskan, Hikmet Eda
Tezer Tekce, Yasemin
Eren Kutsoylu, Oya Ozlem
EgelI, Tufan
Ari, Alpay
Albayrak, Yurdagul
Cabadak, Hatice
Deniz, Secil
Demir Onder, Kubra
KizilateS, Filiz
Ozger, Selcuk
Guzel Tunccan, Ozlem
Haberal, Mehmet
Keywords: Solid-organ transplant recipients
drug-resistant
bacteremia
Blood-Stream Infection
Outcomes
Liver
Publisher: Tubitak Scientific & Technical Research Council Turkey
Abstract: Background/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients' records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients (n = 109), early-onset bacteremia was recorded in 45% (n = 77) of the episodes. In multivariate analysis, catheter-associated bacteremia was an independent risk factor for 7-day mortality (p = 0.037), and early-onset bacteremia was found as an independent risk factor for 30-day mortality (p = 0.017). Conclusion: Difficult-to-treat infections due to XDR bacteria in SOT recipients shadow the success of transplantation. Central venous catheters seem to be the main risk factor. Judicious use of medical devices is of pivotal importance.
URI: https://doi.org/10.3906/sag-2101-161
https://search.trdizin.gov.tr/yayin/detay/480657
https://hdl.handle.net/11499/46081
ISSN: 1300-0144
1303-6165
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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