Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46082
Title: The Potent Cytotoxic and Oxidative Effects of beta-2 Selective ICI-118,551 on Breast Adenocarcinoma Cell Lines with Different Aggressiveness
Authors: Kavakcıoğlu Yardımcı, Berna
Keywords: Esmolol
ICI-118,551
nadolol
breast adenocarcinoma
Apoptosis
Propranolol
Cancer
Proliferation
Metoprolol
Adipogenesis
Quantitation
Antagonist
Induction
Nebivolol
Publisher: Marmara Univ, Inst Health Sciences
Abstract: Objective: Beta-blockers are a group of drugs used in the treatment of cardiovascular diseases. On the other hand, the potential anticancer effects of these drugs have become increasingly important in recent two decades. In this paper, the effects of beta-1 selective esmolol, beta-2 selective ICI-118,551 and non-selective nadolol on breast cancer cell lines with different aggressiveness were investigated for the first time. Methods: A standard spectrophotometricMTT assay was used to determine cell viability. Catalase activities and malondialdehyde levels were measured spectrophotometrically based on the reduction of absorbance resulted from hydrogen peroxide decomposition and the formation of thiobarbituric acid - malondialdehyde product, respectively. Results: It was found that beta-2 selective ICI-118,551 was the most effective one among investigated blockers against MCF-7 and MDA-MB-231 cell lines. Additionally, it was seen that 50-150 mu M ICI-118,551 treatment for 48 hours significantly changed catalase activities and malondialdehyde levels in both breast cancer cell lines in favour of radical production. Conclusion: The obtained results showed that beta-2 adrenergic receptor specific antagonism plays a significant role in beta-blocker induced breast cancer cell death. The outstanding suppression in catalase activities and concomitant increase in radical levels appear to contribute to potent cytotoxic effect of ICI-118,551 on breast adenocarcinoma. Consequently, it can be clearly interpreted that ICI-118,551 may be a valuable option in the treatment of breast cancer.
URI: https://doi.org/10.33808/clinexphealthsci.775323
https://search.trdizin.gov.tr/yayin/detay/480658
https://hdl.handle.net/11499/46082
ISSN: 2459-1459
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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