Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46177
Title: Determination of COVID-19 PCR positivity and mutation status in coronaVacvaccinated individuals in Turkey
Authors: Caliskan, Ahmet
Secme, Mucahit
Kaleli, Ilknur
Sari, Tugba
Oner, Sedef Zeliha
Yaka, Saniye Kucukakin
Donmez, Busra
Keywords: SarsCov-2
CoronaVac vaccine
Sinovac
variant virus
Turkey
Membrane-Protein
Sars-Cov-2
Variants
Vaccine
Publisher: Tubitak Scientific & Technical Research Council Turkey
Abstract: Background/aim: CoronaVac is an inactivated virus-based COVID-19 vaccine used in Turkey and approved for emergency use by the World Health Organization (WHO). In this study, it was aimed to retrospectively evaluate the mutation status and clinical status in individuals who received two doses of CoronaVac vaccine and were infected with COVID-19 at least two weeks after the second dose. Materials and methods: 164 people were included in the study and COVID-19 diagnosis and mutation analyses were determined by RT-PCR using the Bioseepdy SARS CoV-2 Double Gene RT-qPCR Kit and the Biospeedy SARS-CoV-2 Variant Plus kit in accordance with the protocol determined by the manufacturer. Results: 116 (70.7%) UK (Alpha, B.1.1.7) mutation and 3 (1.8%) South Africa (Beta, B.1.351), Brazil (Gamma, P.1) mutations were determined in 164 double doses CoronaVac vaccinated patients; 45 (27.5%) patients were mutation negative. Nine patients (5.5%) developed pneumonia. Eight patients (4.9%) had CT findings compatible with corona virus infection. Seven (4.3%) of the patients received treatment in the intensive care unit, and 5 (3%) of the patients were intubated. Conclusions: In conclusion, people who receive two doses of CoronaVac vaccine can be reinfected with mutant viruses, vaccine significantly reduces the need for hospitalization, CT findings and intensive care.
URI: https://doi.org/10.55730/1300-0144.5344
https://search.trdizin.gov.tr/yayin/detay/536213
https://hdl.handle.net/11499/46177
ISSN: 1300-0144
1303-6165
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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