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Title: | Frequency of Direct Oral Anticoagulants Usage in Acute Pulmonary Thromboembolism Treatment in Turkey (TUPEDO) | Authors: | Tanriverdi, Elif Tutar, Nuri Senturk, Aysegul Bahadir, Ayse Aksel, Nimet Yetkin, Nur Aleyna Karadeniz, Gulistan Cetin, Nazli Tabaru, Ali Yildirim, Binnaz Zeynep Sen, Hatice Selimoglu Ozcelik, Neslihan Ozsari, Emine Uzer, Fatih Cicek, Tugba Esendagli, Dorina Hocanli, Iclal Kocak, Nagihan Durmus Tapan, Utku Kurt, Bahar Arinc, Sibel Kavas, Murat Sahin, Fusun Ergun, Dilek Ucar, Elif Yilmazel) Kilic, Talat Gulmez, Inci Emre, Julide Celdir Dogan, Deniz Ozdemir, Fatma Duger, Mustafa Alzafer, Suha Yarar, Esra Unat, Damla Serce Salik, Bilge |
Keywords: | Venous Thromboembolism Rivaroxaban Warfarin Dabigatran Management |
Publisher: | Galenos Publ House | Abstract: | Background: Direct oral anticoagulants (DOACs) have been used in acute pulmonary thromboembolism as an alternative to warfarin due to drug interactions, narrow therapeutic range, and necessary close International Normalized Ratio (INR) monitoring. Phase 3 study results have reported that these drugs are at least as effective as warfarin and beneficial in terms of bleeding; however, studies that present up-to-date life data are necessary. Aims: To evaluate the frequency of using DOACs, which are prescribed with a limited number of indications in our country, and real-life data results. Study Design: Cross-sectional study Methods: This cross-sectional survey collected the clinical data (history, current treatment, treatment duration, etc.) of patients with pulmonary thromboembolism and who applied to the physician for follow-up between October 15, 2019, and March 15, 2020. The researchers kept the patient records sequentially. Results: Data from 836 patients with acute pulmonary thromboembolism from 25 centers were collected, and DOAC was used in 320 (38.5%) of them. The most preferred DOAC was rivaroxaban (n = 294, 91.9%). DOAC was mostly preferred because it could not provide an effective INR level with warfarin (n=133, 41.6%). Bleeding was observed in 13 (4%) patients. Conclusion: The use of direct oral anticoagulants is becoming almost as widespread as conventional therapy. Real-life data results are important for their contribution to clinical practice. | URI: | https://doi.org/10.4274/balkanmedj.galenos.2021.2021-10-19 https://search.trdizin.gov.tr/yayin/detay/1133635 https://hdl.handle.net/11499/46202 |
ISSN: | 2146-3123 2146-3131 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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