Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46228
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dc.contributor.authorKarakaya, Yeliz Arman-
dc.contributor.authorOral, Esin-
dc.date.accessioned2023-01-09T21:10:05Z-
dc.date.available2023-01-09T21:10:05Z-
dc.date.issued2021-
dc.identifier.issn0377-4929-
dc.identifier.issn0974-5130-
dc.identifier.urihttps://doi.org/10.4103/IJPM.IJPM_980_19-
dc.identifier.urihttps://hdl.handle.net/11499/46228-
dc.description.abstractBackground and Objective: Bladder cancer is the ninth most common type of cancer worldwide. We aimed to investigate the relationship between tumor grade, lamina propria invasion, muscularis propria invasion, and lymphovascular invasion and human epidermal growth factor receptor 2 (HER-2), cyclin D1, and alpha-methyl-CoA racemase (AMACR) expressions in bladder cancer. Materials and Methods: The study included patients who underwent complete TURBT. In total, 72 cases of bladder cancer diagnosed by two pathologists were selected. AMACR, HER-2, cyclin D1 expressions were detected immunohistochemically. Results: The study population comprised 80% (57) males and 20% (15) females (mean age, 68 years). Further, 35 cases were noninvasive and 37 invasive urothelial carcinoma and 38 patients had low-grade tumor and 34 high-grade tumor. Intense immunostaining was observed with cyclin D1 for 75% tumors, AMACR for 39%, and HER-2 for 86%. High expressions of cyclin D1 and AMACR were observed in high-grade tumors (P < 0.05 and P < 0.005, respectively). High expression of HER-2 (2 and 3 positive) was found both at low- and high-grade tumors (84% and 88%, respectively). Conclusion: Cyclin D1, AMACR expressions were found to be significant predictive factors of high-grade tumors. High Her-2 expression in patients with bladder carcinoma may indicate that they are potential targets for treatment. These markers may be important in determining prognosis of tumors and may be valuable for guiding treatment options.en_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Pathology And Microbiologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-methyl-CoA racemaseen_US
dc.subjectbladder canceren_US
dc.subjectcyclin D1en_US
dc.subjecthuman epidermal growth factor receptor 2en_US
dc.subjectMethylacyl-Coa Racemaseen_US
dc.subjectTransitional-Cell Carcinomaen_US
dc.subjectReceptor 2 Expressionen_US
dc.subjectTrastuzumaben_US
dc.subjectCanceren_US
dc.subjectAssociationen_US
dc.subjectMulticenteren_US
dc.subjectGemcitabineen_US
dc.subjectPaclitaxelen_US
dc.subjectCisplatinen_US
dc.titleCorrelation of cyclin D1, HER2, and AMACR expressions with histologic grade in bladder urothelial carcinomasen_US
dc.typeArticleen_US
dc.identifier.volume64en_US
dc.identifier.issue1en_US
dc.identifier.startpage84en_US
dc.identifier.endpage90en_US
dc.identifier.doi10.4103/IJPM.IJPM_980_19-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid56464098200-
dc.authorscopusid57221552851-
dc.identifier.pmid33433414en_US
dc.identifier.scopus2-s2.0-85099465770en_US
dc.identifier.wosWOS:000609889300015en_US
dc.identifier.scopusqualityQ4-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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