Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46263
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dc.contributor.authorAyse, Ugur-
dc.contributor.authorAziz, Gultekin-
dc.contributor.authorDogangun, Yuksel-
dc.date.accessioned2023-01-09T21:10:18Z-
dc.date.available2023-01-09T21:10:18Z-
dc.date.issued2021-
dc.identifier.issn1869-3474-
dc.identifier.issn1869-3482-
dc.identifier.urihttps://doi.org/10.1007/s13139-021-00687-6-
dc.identifier.urihttps://hdl.handle.net/11499/46263-
dc.description.abstractPurpose The generator product radionuclide gallium-68(Ga-68) is widely used for PET/CT imaging agents and the Ga-68-labeled MAA is an attractive alternative to Tc-99m-labeled MAA. Using a commercially available MAA labeling kit for Tc-99m, we presented a reliable synthesis protocol with a highly efficient, organic solvent-free cationic method in GMP conditions in the Scintomics automated synthesis unit. Methods The labeling process was performed by incubating for 7 min at 90 degrees C in the borax vial containing the generator product (GaCl3)-Ga-68 MAA-HEPES eluted from the PSH+ cartridge with 1.5 mL 5 molar NaCl. Quality control of the final product content was examined, and radiopharmaceutical production was carried out in accordance with GMP guidelines. Results Ga-68 eluted from the generator was obtained in more than 99% radiochemical purity and efficiency. In this case, the labeling efficiency was found to be >99%. When the results of SEM-EDX analysis in the final product were examined, it was determined that most of toxic metals were no appreciable in the product content. Conclusions The radiochemical and chemical purity of the final product allows direct use without purification steps to remove free Ga-68 or other toxic compounds.en_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofNuclear Medicine And Molecular Imagingen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGallium-68en_US
dc.subjectMAAen_US
dc.subjectMacroaggregated albuminen_US
dc.subjectPositron emission tomographyen_US
dc.subjectRadiopharmaceuticalen_US
dc.subjectLung perfusion scintigraphyen_US
dc.titleHigh-Efficiency Cationic Labeling Algorithm of Macroaggregated Albumin with (68)Galliumen_US
dc.typeArticleen_US
dc.identifier.volume55en_US
dc.identifier.issue2en_US
dc.identifier.startpage79en_US
dc.identifier.endpage85en_US
dc.authoridYUKSEL, DOGANGUN/0000-0003-0983-2834-
dc.authoridGULTEKIN, AZIZ/0000-0002-0311-8077-
dc.identifier.doi10.1007/s13139-021-00687-6-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid56258662100-
dc.authorscopusid57213854346-
dc.authorscopusid57221965823-
dc.authorwosidUğur, Ayşe/ABE-7866-2021-
dc.identifier.pmid33968274en_US
dc.identifier.scopus2-s2.0-85100808098en_US
dc.identifier.wosWOS:000616889500001en_US
dc.identifier.scopusqualityQ2-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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