Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/46266
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sari, Ozlem | - |
dc.contributor.author | Schuettler, Anna | - |
dc.contributor.author | Loennecke, Peter | - |
dc.contributor.author | Bednarski, Patrick J. | - |
dc.contributor.author | Hey-Hawkins, Evamarie | - |
dc.contributor.author | Karakus, Mehmet | - |
dc.date.accessioned | 2023-01-09T21:10:19Z | - |
dc.date.available | 2023-01-09T21:10:19Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0340-4285 | - |
dc.identifier.issn | 1572-901X | - |
dc.identifier.uri | https://doi.org/10.1007/s11243-020-00446-0 | - |
dc.identifier.uri | https://hdl.handle.net/11499/46266 | - |
dc.description.abstract | (R)-[Ru(eta(6)-p-(MeC6H4Pr)-Pr-i)Cl-2{Ph2PNHCH(CH3)(C6H4-4-F)}] (1) and cis-(R,R)-[PtCl2{Ph2PNHCH(CH3)(C6H4-4-F)}(2)] (2) have been obtained by the reaction of the chiral aminophosphine (R)-Ph2PNHCH(CH3)(C6H4-4-F) with [{RuCl(mu-Cl)(eta(6)-p-(MeC6H4Pr)-Pr-i)}(2)] or [PtCl2(cod)] (cod = cycloocta-1,5-diene). Both complexes were characterized by physico-chemical and spectroscopic methods. Compound 1 was also characterized by X-ray crystallography. The antitumor potential of both compounds was investigated by using the crystal violet antiproliferation assay. Complexes 1 and 2 were found to inhibit the growth of three human cancer cell lines, whereby the Ru complex was considerably more potent than the Pt complex, with IC50 values between 1 and 3 and 12-15 mu M, respectively, but still less potent than cisplatin in the same three cell lines. | en_US |
dc.description.sponsorship | Pamukkale University [2015FBE050] | en_US |
dc.description.sponsorship | This study was supported by Pamukkale University (Grant no: 2015FBE050). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Transition Metal Chemistry | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Aminophosphine | en_US |
dc.subject | Ruthenium | en_US |
dc.subject | Platinum | en_US |
dc.subject | Anticancer activity | en_US |
dc.title | Synthesis, structure and in vitro anticancer activity of ruthenium(II) and platinum(II) complexes with chiral aminophosphine ligands | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 299 | en_US |
dc.identifier.endpage | 305 | en_US |
dc.authorid | Hey-Hawkins, Evamarie/0000-0003-4267-0603 | - |
dc.identifier.doi | 10.1007/s11243-020-00446-0 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57188696266 | - |
dc.authorscopusid | 57222013194 | - |
dc.authorscopusid | 7004176074 | - |
dc.authorscopusid | 7004064907 | - |
dc.authorscopusid | 23067098200 | - |
dc.authorscopusid | 57194553448 | - |
dc.authorwosid | Hey-Hawkins, Evamarie/AAP-6882-2021 | - |
dc.authorwosid | KARAKUS, MEHMET/B-2645-2015 | - |
dc.authorwosid | Hey-Hawkins, Evamarie/K-5612-2019 | - |
dc.identifier.scopus | 2-s2.0-85100999520 | en_US |
dc.identifier.wos | WOS:000617382700001 | en_US |
dc.identifier.scopusquality | Q2 | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
crisitem.author.dept | 17.01. Chemistry | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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