Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46304
Title: Surgery for Secondary Hyperparathyroidism. Total or Subtotal?
Authors: Birsen, Onur
Ozban, Murat
Ozden, Akin
Sungurtekin, Ugur
Erdem, Ergun
Kabay, Burhan
Yilmaz, Sevda
Aykota, Muhammed Rasid
Ozgen, Utku
Demirci, Samet
Aydin, Huseyin Cagatay
Keywords: Secondary hyperparathyroidism
Parathyroidectomy
End-stage renal disease
Renal transplantation
Chronic Kidney-Disease
Total Parathyroidectomy
Mineral Metabolism
Mortality
Outcomes
Phosphorus
Dialysis
Calcium
Risk
Pth
Publisher: Springer India
Abstract: Objectives Secondary hyperparathyroidism (sHPT) develops as a result of the chronic parathyroid stimulation associated with hypocalcemia, hyperphosphatemia, or vitamin D deficiency and leads to an increase in parathormone (PTH) synthesis and parathyroid cell proliferation in all of the four glands. Background There are currently three surgical approaches to the treatment of renal hyperparathyroidism: subtotal parathyroidectomy, total parathyroidectomy without autotransplantation, and total parathyroidectomy with autotransplantation. Methods Included in the study were 79 of which 35 underwent a total parathyroidectomy with autotransplantation (TPTX+AT), while 44 patients underwent a subtotal parathyroidectomy (SPTX). Results A significant decrease was noted in PTH, calcium, and phosphate levels following both types of parathyroidectomy. It was observed that PTH and phosphate serum levels were controlled significantly better following a total parathyroidectomy with autotransplantation, and the recurrence rate was higher in the subtotal parathyroidectomy group (14.3% vs. 27.3%). Conclusion Considering its significantly superior outcomes in the short- and long-term, total parathyroidectomy with autotransplantation should be the preferred treatment option in countries where access to kidney transplantation is difficult and where healthcare services are expensive.
URI: https://doi.org/10.1007/s12262-021-02821-2
https://hdl.handle.net/11499/46304
ISSN: 0972-2068
0973-9793
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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