Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46307
Title: The effects of pharmacological accommodation and cycloplegia on axial length and choroidal thickness
Authors: Bahar, Alperen
Pekel, Gokhan
Keywords: Corneal pachymetry
Choroid
Corneal topography
Axial length
eye
Mydriatics/pharmacology
Pilocarpine/pharmacology
Accommodation
ocular
Publisher: Consel Brasil Oftalmologia
Abstract: Purpose: To investigate the effects of pharmacological accommodation and cycloplegia on ocular measurements. Methods: Thirty-three healthy subjects [mean (+/- SD) age, 32.97 (+/- 5.21) years] volunteered to participate in the study. Measurement of the axial length, macular and choroidal thickness, refractive error, and corneal topography, as well as anterior segment imaging, were performed. After these procedures, pharmacological accommodation was induced by applying pilocarpine eye drops (pilocarpine hydrochloride 2%), and the measurements were repeated. The measurements were repeated again after full cycloplegia was induced using cyclopentolate eye drops (cyclopentolate hydrochloride 1%). The correlations between the measurements were evaluated. Results: A significant increase in subfoveal choroidal thickness after applying 2% pilocarpine was identified (without the drops, 319.36 +/- 90.08 mu m; with pilocarpine instillation, 341.60 +/- 99.19 mu m; with cyclopentolate instillation, 318.36 +/- 103.0 mu m; p<0.001). A significant increase in the axial length was also detected (without the drops, 23.26 +/- 0.83 mm; with pilocarpine instillation, 23.29 +/- 0.84 mm; with cyclopentolate instillation, 23.27 +/- 0.84 mm; p=0.003). Comparing pharmacological accommodation and cycloplegia revealed a significant difference in central macular thickness (with pilocarpine instillation, 262.27 +/- 19.34 mu m; with cyclopentolate instillation, 265.93 +/- 17.91 mu m; p=0.016). Pilocarpine-related miosis (p<0.001) and myopic shift (p<0.001) were more severe in blue eyes vs. brown eyes. Conclusion: Pharmacological accommodation may change ocular measurements, such as choroidal thickness and axial length. This condition should be considered when performing ocular measurements, such as intraocular lens power calculations.
URI: https://doi.org/10.5935/0004-2749.20210015
https://hdl.handle.net/11499/46307
ISSN: 0004-2749
1678-2925
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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