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https://hdl.handle.net/11499/46391
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Deniz, Secil | - |
dc.contributor.author | Uysal, Tugba Kevser | - |
dc.contributor.author | Capasso, Clemente | - |
dc.contributor.author | Supuran, Claudiu T. | - |
dc.contributor.author | Ozensoy Guler, Ozen | - |
dc.date.accessioned | 2023-01-09T21:11:17Z | - |
dc.date.available | 2023-01-09T21:11:17Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1475-6366 | - |
dc.identifier.issn | 1475-6374 | - |
dc.identifier.uri | https://doi.org/10.1080/14756366.2021.1924165 | - |
dc.identifier.uri | https://hdl.handle.net/11499/46391 | - |
dc.description.abstract | The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all around the globe. Intriguing, a clinically used drug, acetazolamide (a specific inhibitor of carbonic anhydrase, CA, EC 4.2.1.1), is used to treat high-altitude pulmonary oedema (HAPE), showing a high degree of clinical similarities with the pulmonary disease caused by Covid-19. In this context, this preliminary study aims to provide insights into some factors affecting the Covid-19 patients, such as hypoxaemia, hypoxia as well as the blood CA activity. We hypothesise that patients with Covid-19 problems could show a dysregulated acid-base status influenced by CA activity. These preliminary results suggest that the use of CA inhibitors as a pharmacological treatment for Covid-19 may be beneficial. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.relation.ispartof | Journal Of Enzyme Inhibition And Medicinal Chemistry | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Covid-19 | en_US |
dc.subject | CO2 | en_US |
dc.subject | hypoxia | en_US |
dc.subject | carbonic anhydrase | en_US |
dc.subject | high-altitude pulmonary oedema | en_US |
dc.title | Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection? | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 1230 | en_US |
dc.identifier.endpage | 1235 | en_US |
dc.authorid | Supuran, Claudiu/0000-0003-4262-0323 | - |
dc.identifier.doi | 10.1080/14756366.2021.1924165 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56556385600 | - |
dc.authorscopusid | 57205331788 | - |
dc.authorscopusid | 7003360509 | - |
dc.authorscopusid | 7102904152 | - |
dc.authorscopusid | 56271832500 | - |
dc.identifier.pmid | 34074197 | en_US |
dc.identifier.scopus | 2-s2.0-85107234378 | en_US |
dc.identifier.wos | WOS:000657110400001 | en_US |
dc.identifier.scopusquality | Q2 | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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Is carbonic anhydrase inhibition useful as a complementary therapy of Covid 19 infection.pdf | 1.66 MB | Adobe PDF | View/Open |
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