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https://hdl.handle.net/11499/46413
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yardimci, Berna Kavakcioglu | - |
dc.contributor.author | Geyikoglu, Fatime | - |
dc.contributor.author | Aysin, Ferhunde | - |
dc.contributor.author | Koc, Kubra | - |
dc.contributor.author | Ozek, Nihal Simsek | - |
dc.contributor.author | Kucukatay, Vural | - |
dc.date.accessioned | 2023-01-09T21:11:26Z | - |
dc.date.available | 2023-01-09T21:11:26Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.issn | 1573-4978 | - |
dc.identifier.uri | https://doi.org/10.1007/s11033-021-06409-7 | - |
dc.identifier.uri | https://hdl.handle.net/11499/46413 | - |
dc.description.abstract | beta-blockers having specific affinities to beta-adrenergic receptors are routinely used to treat cardiovascular problems. Additionally, it has been demonstrated that these drugs can be effective in treating apoptosis-related diseases. The current study was conducted to investigate the cytotoxic and apoptotic effects of beta-1 selective esmolol, beta-2 selective ICI-118,551, and non-selective nadolol blockers on the cancerous and healthy lung cells. MTT test was used to evaluate cytotoxicity. Apoptotic actions were examined by using Annexin V-FITC/PI assay, JC-1 staining, ROS test, and the determination of the caspase-4 and -9, Bcl-2, Bax, Bax/Bcl-2, and JNK levels. Although the MRC-5 showed greater resistance than A549 cells, the beta-blockers at 150-250 mu M exhibited different levels of cytotoxic effect on both lung cell lines. Esmolol was found to be the most ineffective blocker and the increases in Bcl-2 protein levels were appeared to be effective in resistance to this drug. The increases in reactive oxygen species (ROS) together with the increase in caspase-4 and Bax protein levels have been shown to play a role in ICI-118,551 induced lung cell death. Nadolol was the most effective blocker increasing the total apoptotic cell population in both lung cells, which was based on both mitochondrial and endoplasmic reticulum stress. When the selectivities of the beta-blockers are considered, it seems that beta-2 specific antagonism predominantly mediated the death of lung cells, and the overwhelming factors causing apoptosis mainly varied depending on the selectivity of the blockers. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBTAK) [218Z071] | en_US |
dc.description.sponsorship | This study was supported by Grants from The Scientific and Technological Research Council of Turkey (TUBTAK) with 218Z071 numbered project. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Molecular Biology Reports | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Esmolol | en_US |
dc.subject | ICI-118 | en_US |
dc.subject | 551 | en_US |
dc.subject | Nadolol | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Lung cells | en_US |
dc.subject | Breast-Cancer | en_US |
dc.subject | Antitumor-Activity | en_US |
dc.subject | Propranolol | en_US |
dc.subject | Proliferation | en_US |
dc.subject | Adipogenesis | en_US |
dc.subject | Chemotherapy | en_US |
dc.subject | Antagonist | en_US |
dc.subject | Activation | en_US |
dc.subject | Induction | en_US |
dc.subject | Ratio | en_US |
dc.title | The cytotoxic and apoptotic effects of beta-blockers with different selectivity on cancerous and healthy lung cell lines | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 4009 | en_US |
dc.identifier.endpage | 4019 | en_US |
dc.authorid | Kavakcıoğlu Yardımcı, Berna/0000-0003-0719-9094 | - |
dc.authorid | Kucukatay, Vural/0000-0002-6850-6281 | - |
dc.identifier.doi | 10.1007/s11033-021-06409-7 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57218207064 | - |
dc.authorscopusid | 9134233700 | - |
dc.authorscopusid | 56786267900 | - |
dc.authorscopusid | 56347670000 | - |
dc.authorscopusid | 35325668200 | - |
dc.authorscopusid | 6603131772 | - |
dc.authorwosid | Kavakcıoğlu Yardımcı, Berna/AAB-8029-2020 | - |
dc.authorwosid | Kucukatay, Vural/ABI-6427-2020 | - |
dc.identifier.pmid | 34136985 | en_US |
dc.identifier.scopus | 2-s2.0-85108059177 | en_US |
dc.identifier.wos | WOS:000662120600005 | en_US |
dc.identifier.scopusquality | Q2 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | 17.01. Chemistry | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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