Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46425
Title: Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
Authors: Cabus, Umit
Secme, Mucahit
Kabukcu, Cihan
Cil, Nazli
Dodurga, Yavuz
Mete, Gulcin
Fenkci, Ibrahim Veysel
Keywords: Apoptosis
Boric acid
Ovarian cancer
Oxidative stress
Induced Oxidative Stress
Dietary Boron
Cisplatin Resistance
Microrna Expression
Apoptosis
Caspase
Cells
Proliferation
Prognosis
Carcinoma
Publisher: Elsevier
Abstract: Purpose: The aim of this study is to determine the therapeutic effects of boric acid cell proliferation, invasion, migration, colony formation, cell cycle and apoptosis mechanisms in ovarian cancer cell line under in vitro conditions. Methods: MDAH-2774 ovarian cancer cells were employed. Real-time PCR test was used to investigate changes in genes and proteins of cell cycle and apoptosis and identified miRNAs under the addition of boric acid. The apoptosis rates were calculated by TUNEL assay. Matrigel invasion, colony formation and Wound healing tests were used to determine invasion and migration. Oxidative stress index value was calculated for oxidative stress. Results: Boric acid inhibited cell proliferation, invasion, migration and colony formation, but induces apoptosis and oxidative stress. Also, the expression of miRNA-21, miRNA-200a, miRNA-130a and mi-RNA-224 (which are indicators of poor prognosis of ovarian cancer) decreased significantly. Conclusion: The potential of boric acid as a natural molecule may supports its effectiveness in reducing adverse effects arising from conventional ovarian cancer treatments.
URI: https://doi.org/10.1016/j.gene.2021.145799
https://hdl.handle.net/11499/46425
ISSN: 0378-1119
1879-0038
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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