Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46506
Title: Changes in serum levels of calcitonin gene-related peptide, adiponectin, and ghrelin in pregnant women with gestational diabetes mellitus
Authors: Can, Ozlem Kosar
Cabus, Umit
Kabukcu, Cihan
Fenkci, Semin
Fenkci, Veysel
Enli, Yasar
Korkmaz, Berker
Keywords: adiponectin
calcitonin gene-related peptide
gestational diabetes mellitus
ghrelin
Insulin-Resistance
Plasma Ghrelin
Glucose-Tolerance
Amylin
Nerves
Hyperglycemia
Metabolism
Receptors
Alpha
Pathophysiology
Publisher: Wiley
Abstract: Aim This study was designed to determine serum calcitonin gene-related peptide (CGRP) levels and define whether serum CGRP concentration is associated with adiponectin and ghrelin in pregnant women with gestational diabetes mellitus (GDM). Study Design Thirty-six pregnant women with GDM and 43 normal pregnant women without glucose intolerance were evaluated in this study. The serum concentration of CGRP, adiponectin, and ghrelin were measured in two groups at the last trimester of gestation. Main Findings The serum CGRP level in the GDM group was significantly higher than the control group. Serum levels of adiponectin and ghrelin in the GDM group were significantly lower than in the control group. In pregnant women with GDM, there was a significant negative correlation between serum CGRP level and adiponectin level. However, the correlation between maternal serum CGRP levels and ghrelin levels was not significant. Conclusion Our investigation shows that serum CGRP level was significantly higher in pregnant women with GDM in comparison with the control group. These results suggest that CGRP may play a very important role in GDM pathogenesis.
URI: https://doi.org/10.1111/jog.15016
https://hdl.handle.net/11499/46506
ISSN: 1341-8076
1447-0756
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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