Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46531
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dc.contributor.authorArikan, Cuneyt-
dc.contributor.authorYilmaz, Atakan-
dc.contributor.authorOzen, Mert-
dc.contributor.authorSeyit, Murat-
dc.contributor.authorTurkcuer, Ibrahim-
dc.contributor.authorDemirozogul, Ezgi-
dc.date.accessioned2023-01-09T21:12:27Z-
dc.date.available2023-01-09T21:12:27Z-
dc.date.issued2021-
dc.identifier.issn1334-5605-
dc.identifier.issn1845-206X-
dc.identifier.urihttps://doi.org/10.22514/sv.2021.040-
dc.identifier.urihttps://hdl.handle.net/11499/46531-
dc.description.abstractBackground: Treatment provided in an emergency department is aimed at alleviating pain immediately with minimized adverse effects as well as warding off further migraine attacks. The primary aim of this article is to compare the effectiveness of oral paracetamol versus zolmitriptan in treating acute migraine attacks. Methods: This prospective, randomized, and controlled study was carried out at a tertiary care hospital visited by 95,000 patients annually. The study recruited 200 participants who were randomized into two groups. One group received 1000 mg paracetamol while the other group received 2.5 mg zolmitriptan orally. Baseline pain scores were recorded using the Visual Analogue Scale (VAS) and Numeric Rating Scale (NRS) at 15, 30 and at 60 min following administration of the study drugs. Patients requiring further treatment were provided fentanyl at a dosage of 1 mu g/kg as a rescue therapy. Results: A significant decrease was evident in VAS and NRS scores following the administration of the study drugs in both groups (P < 0.001). The change in VAS pain scores after 15, 30 and 60 min was calculated as 17.0 +/- 13.9, 41.2 +/- 16.3 and 61.2 +/- 17.5 mm, respectively, in the paracetamol group and 14.2 +/- 11.7, 39.2 +/- 17.9 and 59.2 +/- 19.3 mm, respectively, in the zolmitriptan group, which did not indicate significant differences (P = 0.103, P = 0.425, P = 0.483, respectively). Likewise, NRS pain scores showed a downward trend in line with VAS pain scores and did not yield a significant difference (P = 0.422). No significant difference concerning rescue therapy was noted between the two groups (P = 0.596). Conclusion: Oral paracetamol and zolmitriptan prove to be similarly effective and have low incidence of acute side effects in treating acute migraine cases without aura.en_US
dc.description.sponsorshipPamukkale University Scientific Research Project Unit [2015TPF039]en_US
dc.description.sponsorshipThis work was supported by the Pamukkale University Scientific Research Project Unit (Numbered 2015TPF039).en_US
dc.language.isoenen_US
dc.publisherMre Pressen_US
dc.relation.ispartofSigna Vitaeen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEmergency departmenten_US
dc.subjectMigraineen_US
dc.subjectParacetamolen_US
dc.subjectZolmitriptanen_US
dc.subjectClinical Pharmacokineticsen_US
dc.subjectUnited-Statesen_US
dc.subject311c90en_US
dc.subjectImpacten_US
dc.subjectTolerabilityen_US
dc.subjectPrevalenceen_US
dc.subjectHeadacheen_US
dc.titleOral paracetamol versus zolmitriptan to treat acute migraine attack in the emergency departmenten_US
dc.typeArticleen_US
dc.identifier.volume17en_US
dc.identifier.issue5en_US
dc.identifier.startpage110en_US
dc.identifier.endpage116en_US
dc.authoridArıkan, Cüneyt/0000-0001-6823-5357-
dc.identifier.doi10.22514/sv.2021.040-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57203267624-
dc.authorscopusid55554611400-
dc.authorscopusid36993995700-
dc.authorscopusid48161777700-
dc.authorscopusid14011949400-
dc.authorscopusid57203263452-
dc.authorwosidArıkan, Cüneyt/GVT-8872-2022-
dc.identifier.scopus2-s2.0-85115297296en_US
dc.identifier.wosWOS:000697049100016en_US
dc.identifier.scopusqualityQ3-
item.openairetypeArticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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