Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46539
Title: Transcranial magnetic stimulation over orbitofrontal cortex in obsessive compulsive disorder: A double-blind placebo-controlled trial
Authors: Ziblak, Alper
Tumkaya, Selim
Kashyap, Himani
Keywords: Obsessive compulsive disorder
TMS
Orbitofrontal cortex
Metaanalysis
Scale
Rtms
Ocd
Excitability
Reliability
Turkish
Brain
Publisher: Elsevier
Abstract: In this study, the effectiveness of low frequency (1 Hz) rTMS application to the orbitofrontal cortex (OFC) was investigated in medication-resistant OCD. Thirty-four medication-resistant OCD patients were divided into two groups in a crossover design. One group started with active rTMS, while the other started with sham rTMS, before crossing over at two weeks. rTMS application was added to the pharmacological treatments used by the patients. While there was a significant decrease in YBOCS total scores in the group which received TMS between Week 0 and 2, the decrease in the sham TMS group did not reach significance. There was a statistically significant decrease in YBOCS total scores in both groups between Weeks 2 and 4. In addition, the two groups did not differ from each other in terms of percentage change in scale scores between Weeks 0 and 2, Weeks 2 and 4, and Weeks 0 and 4. The results of this study suggest that rTMS applied at 1 Hz targeting the OFC is not effective for medication-resistant OCD. Future studies with the use of coils allowing deeper stimulation, higher-frequency stimulation, and longer duration of treatment may provide useful information in this regard.
URI: https://doi.org/10.1016/j.jocrd.2021.100687
https://hdl.handle.net/11499/46539
ISSN: 2211-3649
2211-3657
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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