Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46563
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dc.contributor.authorCoskun, Cagil-
dc.contributor.authorTokgun, Onur-
dc.date.accessioned2023-01-09T21:15:23Z-
dc.date.available2023-01-09T21:15:23Z-
dc.date.issued2021-
dc.identifier.issn0231-5882-
dc.identifier.issn1338-4325-
dc.identifier.urihttps://doi.org/10.4149/gpb_2021023-
dc.identifier.urihttp://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/46563-
dc.description.abstractAstrocytes are greatly impacted by oxidative stress, which can also be related to neurodegenerative diseases. Therefore, preventing the production of reactive oxygen species (ROS) is crucial for maintaining healthy cells. Large conductance Ca2+-activated big potassium (BK) channel openers are effective in eliminating the effects of oxidative stress. The present study aims to determine if NS11021, a BK channel opener, protects the astrocytcs from harmful effects of hydrogen peroxide (H2O2), which is an oxidative stress inducer. For this purpose, primary astrocyte cultures were incubated with H2O2, NS11021, and Iberiotoxin both separately and together. H2O2 decreased cell viability by approximately 50% and increased the number of ROS-positive astrocytes. However, NS11021, but not Iberiotoxin, reversed the deleterious effects of H2O2 on cell viability and decreased ROS production. Moreover, dysregulations in Cyclin D1/CDK6/p21 gene expressions under conditions of oxidative stress were regulated again by the opener. To the best of our knowledge, this study has been the first to reveal that NS11021 reversed the deleterious effects of H2O2 on cell viability by regulating ROS production in astrocytcs. Its effect may also be related to the regulation of cell cycle at the transcriptional level. NS11021 may also be used as an agent for the treatment of oxidative-stress related dysfunction of astrocytes.en_US
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.ispartofGeneral Physiology And Biophysicsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstrocytesen_US
dc.subjectBK channelsen_US
dc.subjectNS11021en_US
dc.subjectOxidative stressen_US
dc.subjectInduced Oxidative Stressen_US
dc.subjectHydrogen-Peroxideen_US
dc.subjectPotassium Channelsen_US
dc.subjectLarge-Conductanceen_US
dc.subjectK+ Channelsen_US
dc.subjectDeathen_US
dc.subjectActivationen_US
dc.subjectAciden_US
dc.titleBK channel opener protects cell viability by regulating reactive oxygen levels in astrocyte cellsen_US
dc.typeArticleen_US
dc.identifier.volume40en_US
dc.identifier.issue5en_US
dc.identifier.startpage409en_US
dc.identifier.endpage417en_US
dc.identifier.doi10.4149/gpb_2021023-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57188698668-
dc.authorscopusid36961438000-
dc.identifier.pmid34602454en_US
dc.identifier.scopus2-s2.0-85117557250en_US
dc.identifier.wosWOS:000704283000006en_US
local.message.claim2023-05-16T11:06:04.114+0300|||rp00970|||submit_approve|||dc_contributor_author|||None*
dc.identifier.scopusqualityQ3-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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