Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/46568
Title: | The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group | Authors: | Turgutalp, Kenan Cebeci, Egemen Turkmen, Aydin Derici, Ulver Seyahi, Nurhan Eren, Necmi Dede, Fatih Gullulu, Mustafa Sahin, Gulizar Manga Yilmaz, Murvet Sipahi, Savas Sahin, Garip Ulu, Sena Tatar, Erhan Gundogdu, Ali Kazancioglu, Rumeyza Turan Sevinc, Can Gungor, Ozkan Sahin, Idris Kutlay, Sim Kurultak, Ilhan Aydin, Zeki Altun, Bulent Dursun, Belda Yilmaz, Zulfikar Uzun, Ozcan Suleymanlar, Gultekin Candan, Ferhan Sezer, Siren Tanburoglu, Derya Basak Bahcebasi, Zerrin Bicik Taymez, Dilek Akcali, Esra Oygar, Deren Istemihan, Zulal Bardak, Simge Akcay, Omer Faruk Dincer, Mevlut Tamer Dervisoglu, Erkan Yenigun, Ezgi Turkmen, Kultigin Ozturk, Savas |
Keywords: | IgA nephropathy Glomerular IgG staining Renal prognostic factors Oxford Classification O-Glycosylation Deposition |
Publisher: | Bmc | Abstract: | Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors. | URI: | https://doi.org/10.1186/s12882-021-02560-2 https://hdl.handle.net/11499/46568 |
ISSN: | 1471-2369 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
s12882-021-02560-2.pdf | 751.25 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
2
checked on Dec 14, 2024
WEB OF SCIENCETM
Citations
3
checked on Dec 20, 2024
Page view(s)
34
checked on Aug 24, 2024
Download(s)
20
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.