Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46568
Title: The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group
Authors: Turgutalp, Kenan
Cebeci, Egemen
Turkmen, Aydin
Derici, Ulver
Seyahi, Nurhan
Eren, Necmi
Dede, Fatih
Gullulu, Mustafa
Sahin, Gulizar Manga
Yilmaz, Murvet
Sipahi, Savas
Sahin, Garip
Ulu, Sena
Tatar, Erhan
Gundogdu, Ali
Kazancioglu, Rumeyza Turan
Sevinc, Can
Gungor, Ozkan
Sahin, Idris
Kutlay, Sim
Kurultak, Ilhan
Aydin, Zeki
Altun, Bulent
Dursun, Belda
Yilmaz, Zulfikar
Uzun, Ozcan
Suleymanlar, Gultekin
Candan, Ferhan
Sezer, Siren
Tanburoglu, Derya Basak
Bahcebasi, Zerrin Bicik
Taymez, Dilek
Akcali, Esra
Oygar, Deren
Istemihan, Zulal
Bardak, Simge
Akcay, Omer Faruk
Dincer, Mevlut Tamer
Dervisoglu, Erkan
Yenigun, Ezgi
Turkmen, Kultigin
Ozturk, Savas
Keywords: IgA nephropathy
Glomerular IgG staining
Renal prognostic factors
Oxford Classification
O-Glycosylation
Deposition
Publisher: Bmc
Abstract: Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.
URI: https://doi.org/10.1186/s12882-021-02560-2
https://hdl.handle.net/11499/46568
ISSN: 1471-2369
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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