Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46570
Title: Serum Hepcidin and Prohepcidin Levels in Nonfebrile and Febrile Neutropenia
Authors: Koluman, Basak Unver
Avci, Esin
Guler, Nil
Cagliyan, Gulsum Akgun
Senol, Hande
Keywords: Hepcidin
Prohepcidin
Neutropenia
Febrile neutropenia
Iron-Metabolism
Key Regulator
Anemia
Inflammation
Management
Expression
Diagnosis
Mediator
Publisher: Coll Physicians & Surgeons Pakistan
Abstract: Objective: To compare the prohepcidin and hepcidin levels in the afebrile neutropenic period and neutropenic fever in patients with hematological malignancy. Study Design: Descriptive study. Place and Duration of Study: Department of Hematology, Pamukkale University Hospital, Denizli, Turkey, between January 2018 and December 2019. Methodology: Neutropenic patients were compared with a healthy control group. Prohepcidin and hepcidin serum levels were to be measured in neutropenic and control groups. When fever occurred in neutropenic group, serum was taken again and the same values were compared, in addition to procalcitonin and CRP values. Results: Prohepcidin and hepcidin levels were found to be significantly higher in the neutropenic group (n = 53) than the control group [n = 44, (med:166.65 ng/ml, IQR:147.66 - 187.38 ng/ml vs. med:47.49 ng/ml, IQR:15.61 - 82.51 ng/ml; p <0.001); (med:315 ng/ml, IQR:314.92 - 315 ng/ml vs. med:26.61 ng/ml, IQR:4.69 - 66.83 ng/ml; p <0.001)]. No significant difference was found in terms of these two analyses (167.29 +/- 29.31 ng/mlvs. 167.15 +/- 27.61 ng/ml; p = 0.979; 296.21 +/- 37.19 ng/mlvs 299.16 +/- 37.68 ng/ml; p= 0.629) in the neutropenic fever period compared to the afebrile neutropenic period. In neutropenic fever patients, procalcitonin and CRP (C-reactive protein) were found significantly higher than the afebnile neutropenic group (0.7 +/- 1.2 ng/ml vs. 0.25 +/- 0.76 ng/ml; p = 0.034; 10.27 +/- 9.93 mg/dl vs 2.61 +/- 2.78 mg/dl; p <0.001). Conclusion: Although there was no significant difference between afebnile neutropenia and neutropenic fever in patients in terms of hepcidin and prohepcidin levels, higher levels were found in both groups compared to the control group.
URI: https://doi.org/10.29271/jcpsp.2021.11.1303
https://hdl.handle.net/11499/46570
ISSN: 1022-386X
1681-7168
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
Bulletin_pdf.pdf162.08 kBAdobe PDFView/Open
Show full item record



CORE Recommender

Page view(s)

60
checked on Aug 24, 2024

Download(s)

28
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.