Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46596
Title: Investigation of blood leptin and adropin levels in patients with multiple sclerosis A CONSORT-clinical study
Authors: Cinkir, Ufuk
Bir, Levent Sinan
Topsakal, Senay
Cicek, Esin Avci
Tekin, Selma
Keywords: adipokine
biomarker
inflammation
mammalian target of rapamycin
neurodegeneration
Huntingtons-Disease
Akt
Prevalence
Activation
Pathway
Mtor
Survival
Akt/Pkb
Kinase
Cells
Publisher: Lippincott Williams & Wilkins
Abstract: Background: The effects of adipokines have been investigated in multiple sclerosis (MS) in the literature. Results are uncertain, and subgroups like adropin have not been previously studied. We primarily aimed to determine leptin and adropin levels in MS and their potential use as a biomarker. Methods: This study was an experimental research. While 44 MS patients diagnosed according to McDonald criteria were included in the patient group, 40 people without MS diagnosis and risk factors took part in the control group. Demographic data, height, weight, body mass index, blood glucose, thyroid-stimulating hormone, alanine transaminase, aspartate transaminase, creatinine, low-density lipoprotein, leptin, adropin levels, presence of hypertension, diabetes mellitus, coronary artery disease were recorded. Expanded disability status scale and disease duration were also evaluated in the patient group. Our data were presented as mean +/- standard deviations. Results: The mean blood leptin value of the patient group (6.12 +/- 5.34 ng/mL) was significantly lower than the value of the control group (13.02 +/- 8.25 ng/mL) (P < .001). The patient group had a mean adropin level of 504.12 +/- 311.17 ng/mL, which was significantly lower than that of the control group (747.0 +/- 309.42 ng/mL) (P < .001). Statistically insignificant differences were found between their body mass index, glucose, alanine transaminase, aspartate transaminase, thyroid-stimulating hormone, low-density lipoprotein levels (P > .001). Conclusion: This is the first study that has evaluated adropin levels in patients with MS. The relationship between MS and leptin levels is still unclear. Therefore, our study might be helpful to elucidate MS pathogenesis and provide supportive criteria for diagnosis.
URI: https://doi.org/10.1097/MD.0000000000027247
https://hdl.handle.net/11499/46596
ISSN: 0025-7974
1536-5964
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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