Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46621
Title: The effectiveness of gamma knife radiosurgery for the management of residual high-grade gliomas: A single institutional study
Authors: Yakar, Fatih
Egemen, Emrah
Dere, Umit A.
Saginc, Halil
Gokdeniz, Ulas
Bakirarar, Batuhan
Gokdeniz, Ceyda G.
Baltalarli, Bahar
Coskun, Mehmet E.
Acar, Feridun
Keywords: Glioblastoma
Progression-free survival
Radiosurgery
Radiotherapy
Central-Nervous-System
Randomized Phase-Iii
Stereotactic Radiosurgery
Glioblastoma-Multiforme
Adjuvant Temozolomide
Malignant Gliomas
Primary Brain
Radiotherapy
Survival
Tumors
Publisher: Elsevier Sci Ltd
Abstract: High-grade gliomas (HGGs) are presently managed via surgical resection, external beam radiation therapy (EBRT), and chemotherapy. Although Gamma Knife radiosurgery (GKRS) is currently used to manage HGGs, it has not been considered standard care. This paper aims to compare the contribution of GKRS to clinical outcomes in patients in which gross total resection (GTR) cannot be achieved. We retrospectively reviewed the data of 99 patients with HGG (World Health Organization (WHO) grade III and IV) from two groups: group 1 consisted of 68 patients for which only EBRT was administered, and group 2 consisted of 31 patients for which EBRT and GKRS were administered. Patient demographic data, the extent of resection, IDH mutation, radiation dosage, progression-free survival (PFS), overall survival (OS), and follow-up time were recorded and compared across groups. The grade III/IV tumor ratio was 10/58 and 10/21 in groups 1 and 2, respectively. In group 2, PFS and OS were higher than in group 1 (P = 0.030 and 0.021). The mean follow-up time was 15.02 +/- 11.8 (3-52) and 18.9 +/- 98.6 (7-43) months in groups 1 and 2, respectively. In addition to the standard management of HGGs in patients without GTR, boost GKRS during the early postoperative period is beneficial for increasing PFS and OS. (c) 2021 Published by Elsevier Ltd.
URI: https://doi.org/10.1016/j.jocn.2021.12.015
https://hdl.handle.net/11499/46621
ISSN: 0967-5868
1532-2653
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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