Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46845
Title: Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group
Authors: Yildiz, Abdulmecit
Ulu, Sena
Oruc, Aysegul
Ucar, Ali Riza
Ozturk, Savas
Alagoz, Selma
Eren, Necmi
Kocyigit, Ismail
Cevher, Simal Koksal
Haras, Ali Burak
Sumnu, Abdullah
Arinsoy, Turgay
Sahin, Garip
Suleymanlar, Gultekin
Cavdar, Caner
Sahin, Gizem Kumru
Kurultak, Ilhan
Unsal, Abdulkadir
Sahin, Gulizar
Kazan, Sinan
Tatar, Erhan
Dikec, Mehmet
Dursun, Belda
Sayarlioglu, Hayriye
Turkmen, Kultigin
Artan, Ayse Serra
Aktas, Nimet
Yilmaz, Zulfikar
Behlul, Ahmet
Dheir, Hamad
Kutlay, Sim
Seyahi, Nurhan
Keywords: Histopathology
immunofluorescence
primary membranous nephropathy
nephrotic syndrome
Turkey
kidney biopsy
Renal Pathology
Journey
Publisher: Taylor & Francis Ltd
Abstract: Background We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people. Methods This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed. Results A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 +/- 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m(2) (IQR, 75.4-116.3), and median proteinuria was 6000 mg/d (IQR, 3656-9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed. Conclusions Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.
URI: https://doi.org/10.1080/0886022X.2022.2079526
https://hdl.handle.net/11499/46845
ISSN: 0886-022X
1525-6049
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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