Interleukin-1 gene (IL-1) polymorphism in patients with Behcet's Disease, and its relationship with disease manifestations

Abstract

Objective: The objective of this study was to investigate whether interleukin-1 (IL-1) gene polymorphisms are associated with susceptibility to Behcet's disease (BD) and clinical manifestations of the disease. Methods: In this cross-sectional study, we enrolled 110 patients with BD and age-and gender-matched 120 healthy controls. Five polymorphic regions of the IL-1 gene including rs 1800587 (IL1A-889 C/T), rs 2234650 (IL1R1), rs 16944 (IL1B-511 C/T), rs 315952 (IL1RN), and rs 1143634 (IL1B-3954 C/T) were analyzed by using the real-time polymerase chain reaction system. Allele frequencies and genotypes were compared between groups. p <= 0.05 was accepted as statistically significant. Results: The mean age of the patients with BD was 41 +/- 12.4 years. The two groups were similar in terms of the age and gender distribution. The vast majority of BD patients had mucocutaneous involvement. The mean disease duration was 83.7 +/- 67.8 months among the patients. The frequencies of each polymorphism in the IL-1 gene were similar between patients with BD and healthy controls. Conclusion: The frequencies of variable IL-1 gene polymorphisms were similar between patients with BD and healthy controls.