Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46929
Title: The Effect of Continuing Chemotherapy after Chemoradiotherapy during the Time to Surgery on Tumor Response and Survival for Local Advanced Rectal Cancer
Authors: Demiray, Atike Goekcen
Yaren, Arzu
Sungurtekin, Ugur
Baltalarli, Papatya Bahar
Demirkan, Nese
Herek, Duygu
Taskoeylue, Burcu Yapar
Dogu, Gamze Goekoez
Degirmencioglu, Serkan
Ozgen, Utku
Saginc, Halil
Cakiroglu, Umut
Ozhan, Nail
Karan, Canan
Demirel, Burcin Cakan
Dogan, Tolga
Ozdemir, Melek
Keywords: Short-Course Radiotherapy
Pathological Complete Response
Preoperative Chemoradiotherapy
Neoadjuvant Chemoradiotherapy
Consolidation Chemotherapy
Randomized-Trial
Delayed Surgery
Stockholm Iii
Prodige 23
Chemoradiation
Publisher: Hindawi Ltd
Abstract: Aim. The current standard treatment of locally advanced rectal carcinoma is total mesorectal excision and postoperative adjuvant chemotherapy after neoadjuvant concurrent chemoradiotherapy (NCRT). Many studies have shown that pathological complete response (pCR) is an important prognostic factor for patients receiving NCRT. Many studies have therefore been conducted to increase pCR rates by changing the perioperative treatment strategies. Prolonging the chemotherapy time may be a reasonable way to increase the effectiveness of NCRT, pCR, and survival rates. We investigated whether neoadjuvant consolidation chemotherapy had an effect on tumor response and survival. Methods. The data of 163 patients diagnosed with locally advanced rectal carcinoma were evaluated. The data of 107 patients (Group 1) who were radiologically T3-T4 and/or N+ and received chemotherapy after NCRT until their operations were compared with the data of 56 patients (Group 2) who were operated after NCRT. Results. Group 1 patients had tumor and node downstaging. Their pCR was found significantly higher than in Group 2 (p=0.005). In Group 1 patients with T3, pCR was significantly higher than for those with T4. The elapsed time between NCRT and surgery was significantly longer in patients with pCR (respectively, p=0.012 and p=0.008). Conclusion. Neoadjuvant consolidation chemotherapy after NCRT is a safe approach that can lead to higher pathological complete response rates. The time until surgery with neoadjuvant consolidation chemotherapy may provide the chance to follow the patient without surgery in addition to increasing pCR.
URI: https://doi.org/10.1155/2022/4108677
https://hdl.handle.net/11499/46929
ISSN: 1687-8450
1687-8469
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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