Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4695
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dc.contributor.authorBaltalarlı, Ahmet-
dc.contributor.authorÖzcan, Vefa-
dc.contributor.authorBir, Ferda-
dc.contributor.authorAybek, Hülya-
dc.contributor.authorSacar, M.-
dc.contributor.authorÖnem, Gökhan-
dc.contributor.authorGökşin, İbrahim-
dc.date.accessioned2019-08-16T11:36:22Z-
dc.date.available2019-08-16T11:36:22Z-
dc.date.issued2006-
dc.identifier.issn0890-5096-
dc.identifier.urihttps://hdl.handle.net/11499/4695-
dc.identifier.urihttps://doi.org/10.1007/s10016-005-9284-0-
dc.description.abstractThe objectives of this study were to compare the protective effects of ascorbic acid and iloprost on lung injury caused by ischemia reperfusion (I/R) of the lower extremities of rats. Wistar albino rats (n = 34) were divided into five groups. In the I/R group (n = 6), the aorta was cross-clamped for 3 hr, followed by 1 hr of reperfusion. In the vitamin C group (n = 8), animals were pretreated with 100 mg/kg ascorbic acid via the left jugular vein before aortic cross-clamping. In the iloprost group (n = 8), animals were pretreated with 20 ng/(kg·min) iloprost by constant intravenous infusion via the left jugular venous cannula. In the sham group (n = 6), the abdomen was left open at the same period and a juguler venous line was established. In the control group (n = 6), lungs were removed and blood samples taken immediately after sternotomy. No treatment was given in this group. After both lungs were removed, biochemical parameters were measured and histopathological evaluation was made. Although the arterial blood pO2 and HCO3 levels were stastistically significantly high in both the vitamin C and iloprost groups compared to the I/R group, plasma malondialdehyde (MDA) levels were significantly low. Meanwhile, the MDA levels in the lung tissue were significantly low in the vitamin C group compared to the I/R group. The MDA level in the lung tissue in the iloprost group was also low compared to the I/R group, but it was not statistically significant. The lungs of the I/R group displayed intense interstitial leukocytic infiltration in histopathological examination compared to the other groups. Pretreatment of animals with iloprost and vitamin C significantly decreased the pulmonary injury characterized by decreased plasma leukocyte sequestration. The results suggest that both vitamin C and iloprost are useful agents for attenuating the lung injury caused by increased oxidative stress and neutrophil accumulation after a period of I/R of the lower extremities. © Annals of Vascular Surgery Inc.en_US
dc.language.isoenen_US
dc.publisherSpringer New Yorken_US
dc.relation.ispartofAnnals of Vascular Surgeryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectascorbic aciden_US
dc.subjectiloprosten_US
dc.subjectmalonaldehydeen_US
dc.subjectredoxanen_US
dc.subjectabdomenen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectaorta clampingen_US
dc.subjectarterial oxygen tensionen_US
dc.subjectarticleen_US
dc.subjectbiochemistryen_US
dc.subjectblood samplingen_US
dc.subjectcannulaen_US
dc.subjectcell infiltrationen_US
dc.subjectcomparative studyen_US
dc.subjectcontrolled studyen_US
dc.subjecthistopathologyen_US
dc.subjectischemiaen_US
dc.subjectjugular veinen_US
dc.subjectlegen_US
dc.subjectleukocyteen_US
dc.subjectlung injuryen_US
dc.subjectlung parenchymaen_US
dc.subjectneutrophilen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjectreperfusionen_US
dc.subjectstatistical significanceen_US
dc.subjectsternotomyen_US
dc.titleAscorbic acid (vitamin C) and iloprost attenuate the lung injury caused by ischemia/reperfusion of the lower extremities of ratsen_US
dc.typeArticleen_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.startpage49-
dc.identifier.startpage49en_US
dc.identifier.endpage55en_US
dc.authorid0000-0002-0635-4251-
dc.authorid0000-0003-4156-4040-
dc.identifier.doi10.1007/s10016-005-9284-0-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid16378148en_US
dc.identifier.scopus2-s2.0-29744433829en_US
dc.identifier.wosWOS:000234299700009en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale_University-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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