Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47060
Title: Analysis of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase L1 in Postmortem Serum and Cerebrospinal Fluid in Traumatic Cerebral Deaths
Authors: Kurtuluş Dereli, Ayşe
Seçme, Mücahit
Acar, Kemalettin
Keywords: Traumatic brain injury
glial fibrillary acidic protein
ubiquitin C-terminal hydrolase L1
autopsy
Brain-Injury
Biomarkers
Blood
Gfap
Ischemia
Utility
Publisher: Marmara Univ, Inst Health Sciences
Abstract: Objective: There is a growing body of research aimed at identifying biological markers that could indicate traumatic cerebral deaths such as traumatic brain damage in the postmortem period. In the event of astrocytic and neuronal injury, glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) are released into cerebrospinal fluid and blood. In the postmortem identification of traumatic brain injury, the present research explores the ability of GFAP and UCH-L1. Methods: Cerebrospinal fluid and blood samples were obtained from medicolegal autopsies, 17 cases with severe head trauma, 9 cases with the non-lethal head trauma group and 18 control cases. UCH-L1 and GFAP levels in postmortem cerebrospinal fluid and serum were determined from an enzyme-linked immunosorbent assay (ELISA). Results: GFAP level in cerebrospinal fluid and serum was 2.68 +/- 0.67 ng/ml and 0.79 +/- 0.92 ng/ml in the lethal head trauma group, 2.74 +/- 0.64 ng/ml and 1.05 +/- 0.68 ng/ml the non-lethal head trauma group and 2.49 +/- 0.55 ng/ml and 1.05 +/- 0.89 ng/ml in the control group, respectively. UCH-L1 level in cerebrospinal fluid and serum was 3.02 +/- 0.68 ng/ml and 2.69 +/- 0.77 ng/ml in the lethal head trauma group, 3.34 +/- 0.70 ng/ml and 2.59 +/- 0.65 ng/ml the non-lethal head trauma group and 3.28 +/- 0.33 ng/ml and 2.74 +/- 0.34 ng/ml in the control group, respectively. Elevated cerebrospinal fluid and serum UCH-L1 and GFAP levels were observed in all cases, although absence of statistically significant difference between the trauma and control groups (p>0.05). Conclusion: Further studies are needed to assess whether postmortem serum and CSF GFAP and UCH-L1 concentrations increase regardless of the cause of death.
URI: https://doi.org/10.33808/clinexphealthsci.943779
https://hdl.handle.net/11499/47060
ISSN: 2459-1459
Appears in Collections:Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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