Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47088
Title: Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study
Authors: Kaymaz, Serdar
Kavas, Murat
Demiray, Aydin
Karasu, Ugur
Cobankara, Veli
Boga, Sibel
Keywords: Interferon-gamma receptor 1
sarcoidosis
polymorphism
T-Cells
Pulmonary Sarcoidosis
Th17 Cells
Ifn-Gamma
Risk
Association
Infection
Cytokines
Promoter
Lymphocytes
Publisher: Turkish League Against Rheumatism
Abstract: Objectives: This study aims to investigate the relationship between the interferon-gamma receptor 1 (IFNGR1) polymorphism and susceptibility to lung sarcoidosis. Patients and methods: The study included a total of 55 patients (13 males, 42 females; mean age: 46.5 +/- 9.1 years; range, 22 to 66 years) with lung sarcoidosis and 28 healthy controls (6 males, 22 females; mean age: 43.9 +/- 5.9 years; range 22 to 60 years) selected from the Turkish population. The polymerase chain reaction was used for genotyping of participants to determine single-nucleotide polymorphisms. Hardy-Weinberg equilibrium, which is considered an important tool for detecting genotyping errors, was tested. Allele and genotype frequencies of patients and controls were compared using logistic regression analysis. Results: The analyses showed no correlation between the tested IFNGR1 single-nucleotide polymorphism (rs2234711) and lung sarcoidosis (p>0.05). The categorization analysis according to the clinical features, laboratory, and radiographic characteristics showed no correlation between the tested polymorphism of IFNGR1 (rs2234711) and these characteristics (p>0.05). Conclusion: The results of the study showed that the tested gene polymorphism (rs2234711) of IFNGR1 was not associated with lung sarcoidosis. More comprehensive studies are needed to verify our results.
Description: Article; Early Access
URI: https://doi.org/10.46497/ArchRheumatol.2022.9239
https://hdl.handle.net/11499/47088
ISSN: 2618-6500
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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