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https://hdl.handle.net/11499/47103
Title: | Therapeutic Effect of Teneligliptin in Drug Induced Nephrotoxicity: An In-Vitro Study | Authors: | Becerir, Tulay Tokgun, Onur Inci, Kubilay Girisgen, Ilknur Yuksel, Selcuk |
Keywords: | gentamicin vancomycin cisplatin drug-induced nephrotoxicity teneligliptin Biomarkers Mechanisms |
Publisher: | Cureus Inc | Abstract: | Background Drug-induced nephrotoxicity is an important side effect of many commonly used drugs. In this study, we planned to evaluate the effects of teneligliptin (TG), which is a dipeptidyl peptidase-4 (DPP-4) inhibitor, on cell healing by creating nephrotoxicity models in human renal proximal tubule cell and human embryonic kidney epithelial cells cell lines in-vitro with cisplatin, vancomycin, and gentamicin. Methodology First, we determined the 50% inhibitory concentration doses of nephrotoxic drugs and the nephroprotective dose of TG. Then, we analyzed the difference in cell viability, apoptosis, and oxidative stress (reactive oxygen and nitrogen species (ROS/RNS) production) between TG-treated and untreated cells after nephrotoxicity occurred. Moreover, we evaluated the expression of kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in cells. Results We found that when cell lines were treated after toxicity was induced with TG, cell viability increased, apoptosis and ROS/RNS production were significantly decreased, and expressions of KIM-1 and NGAL were significantly reduced. Conclusions This study showed that TG has positive effects on the recovery of drug-induced nephrotoxicity in an in-vitro setting. | URI: | https://doi.org/10.7759/cureus.23871 https://hdl.handle.net/11499/47103 |
ISSN: | 2168-8184 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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