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https://hdl.handle.net/11499/47190
Title: | Comparison of Antimicrobial Agents as Therapy for Experimental Endocarditis Caused by Methicillin-Resistant Staphylococcus aureus | Authors: | Sacar, Mustafa Sacar, Suzan Cevahir, Nural Onem, Gokhan Teke, Zafer Asan, Ali Turgut, Huseyin |
Keywords: | Anti-bacterial agents/pharmacology/therapeutic use disease models, animal drug resistance, microbial endocarditis, bacterial/microbiology/drug therapy linezolid methicillin resistance microbial sensitivity tests rodents staphylococcal infections/epidemiology Staphylococcus aureus/drug effects teicoplanin vancomycin Semisynthetic Streptogramin Infective Endocarditis Cardiac Vegetations Rp 59500 Vancomycin Teicoplanin Efficacy Rp-59500 Antibiotics Mechanisms |
Publisher: | Texas Heart Inst | Abstract: | We used an experimental rat model to compare the therapeutic efficacy of teicoplanin, linezolid, and quinupristin/dalfopristin with that of vancomycin as standard therapy for infective endocarditis. Aortic endocarditis was induced in rats by insertion of a polyethylene catheter into the left ventricle, followed by intravenous inoculation of 10(6) colony-forming units of methicillin-resistant Staphylococcus aureus 24 hours later Forty-eight hours after bacterial challenge, intravenous antibiotic therapies were initiated. There were 6 groups of 8 rats each: un-infected control; infected, untreated control; vancomycin-treated (40 mg/kg twice daily); teicoplanin-treated (20 mg/kg twice daily after a loading dose of 40 mg/kg); linezolid-treated (75 mg/kg 3 times daily for 1 day, then 75 mg/kg twice daily); and quinupristin/dalfopristin-treated (30 mg/kg twice daily and an additional 10 mg/kg dalfopristin infusion over 6 to 12 hr daily). At the end of therapy, the aortic valve vegetations in the drug-treated rats were evaluated microbiologically. Compared with the infected, untreated group, all drug-treated groups had significantly reduced bacterial titers in the vegetations. Vancomycin, teicoplanin, and quinupristin/dalfopristin all effectively reduced the quantitative bacterial cultures of aortic valve vegetations. In addition, there was no significant difference in the comparative efficacy of teicoplanin, linezolid, and quinupristin/dalfopristin. Vancomycin significantly reduced bacterial counts in comparison with linezolid, which was nonetheless also effective. Our experimental model showed that each of the investigated antimicrobial agents was effective in the treatment of infective endocarditis. (Tex Heart Inst J 2010;37(4):400-4) | URI: | https://hdl.handle.net/11499/47190 | ISSN: | 1526-6702 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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