Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47190
Title: Comparison of Antimicrobial Agents as Therapy for Experimental Endocarditis Caused by Methicillin-Resistant Staphylococcus aureus
Authors: Sacar, Mustafa
Sacar, Suzan
Cevahir, Nural
Onem, Gokhan
Teke, Zafer
Asan, Ali
Turgut, Huseyin
Keywords: Anti-bacterial agents/pharmacology/therapeutic use
disease models, animal
drug resistance, microbial
endocarditis, bacterial/microbiology/drug therapy
linezolid
methicillin resistance
microbial sensitivity tests
rodents
staphylococcal infections/epidemiology
Staphylococcus aureus/drug effects
teicoplanin
vancomycin
Semisynthetic Streptogramin
Infective Endocarditis
Cardiac Vegetations
Rp 59500
Vancomycin
Teicoplanin
Efficacy
Rp-59500
Antibiotics
Mechanisms
Publisher: Texas Heart Inst
Abstract: We used an experimental rat model to compare the therapeutic efficacy of teicoplanin, linezolid, and quinupristin/dalfopristin with that of vancomycin as standard therapy for infective endocarditis. Aortic endocarditis was induced in rats by insertion of a polyethylene catheter into the left ventricle, followed by intravenous inoculation of 10(6) colony-forming units of methicillin-resistant Staphylococcus aureus 24 hours later Forty-eight hours after bacterial challenge, intravenous antibiotic therapies were initiated. There were 6 groups of 8 rats each: un-infected control; infected, untreated control; vancomycin-treated (40 mg/kg twice daily); teicoplanin-treated (20 mg/kg twice daily after a loading dose of 40 mg/kg); linezolid-treated (75 mg/kg 3 times daily for 1 day, then 75 mg/kg twice daily); and quinupristin/dalfopristin-treated (30 mg/kg twice daily and an additional 10 mg/kg dalfopristin infusion over 6 to 12 hr daily). At the end of therapy, the aortic valve vegetations in the drug-treated rats were evaluated microbiologically. Compared with the infected, untreated group, all drug-treated groups had significantly reduced bacterial titers in the vegetations. Vancomycin, teicoplanin, and quinupristin/dalfopristin all effectively reduced the quantitative bacterial cultures of aortic valve vegetations. In addition, there was no significant difference in the comparative efficacy of teicoplanin, linezolid, and quinupristin/dalfopristin. Vancomycin significantly reduced bacterial counts in comparison with linezolid, which was nonetheless also effective. Our experimental model showed that each of the investigated antimicrobial agents was effective in the treatment of infective endocarditis. (Tex Heart Inst J 2010;37(4):400-4)
URI: https://hdl.handle.net/11499/47190
ISSN: 1526-6702
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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