Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47243
Title: Comparative Analysis of Antioxidant and Anticancer Activities of Fruiting Bodies, Mycelial Biomass and Culture Liquid of Omphalotus olearius OBCC 2503 (Agaricomycetes) from Turkey
Authors: Yamac, Mustafa
Ozturk, Selin Engur
Canturk, Zerrin
Dikmen, Miris
Keywords: Omphalotus olearius
fruiting bodies
mycelial biomass
culture liquid
antioxidant
anticancer
medicinal mushrooms
Chemical-Composition
Medicinal Mushrooms
Extracts
Derivatives
Publisher: Begell House Inc
Abstract: Up to now, the comparative analysis of the antioxidant and anticancer activities of the ethyl acetate extracts from fruiting body, mycelial biomass, and culture liquid of Omphalotus olearius are not reported. In this study, antioxidant activity of different samples was compared by six different methods: DPPH and ABTS radical scavenging activities, metal chelating activity, reducing power, inhibition of beta-carotene bleaching, and lipid perox-idation through ferric thiocyanate assay. Total phenolic contents of the samples were also determined. The mycelial biomass produced in vitro conditions presented the highest activity by five of them which was following by culture liquid. The potential antiproliferative effects of the extracts in cell culture, human cancer (A549, Caco2 and MCF-7) and healthy (CCD-19LU and CCD 841 CoN) cell lines by WST-1 assay was also evaluated. The highest anticancer effects were determined on A549 lung cancer cells treated with mycelial biomass extract and Caco2 colon cancer cells treated with culture liquid extract. The culture liquid was more effective on the cells than mycelial biomass according to IC(50 )values. All tested extracts were also evaluated for their toxicity against brine shrimp larvae (Arte-mia salina). O. olearius culture liquid and mycelial biomass extracts showed highest and lowest toxicity against A. salina, respectively.
URI: https://hdl.handle.net/11499/47243
ISSN: 1521-9437
1940-4344
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tavas Sağlık Hizmetleri Meslek Yüksekokulu Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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