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Title: | Neurobrucellosis | Authors: | Kutlu M. Ergönül Ö. |
Keywords: | Antibiotis in neurobrucellosis Brucella species Brucellosis CNS symptoms in brucellosis Human brucellosis Neurobrucellosis ceftriaxone doxycycline gentamicin rifampicin streptomycin agglutination test apoptosis auditory evoked potential bacterial virulence blood brain barrier Brucella Brucella abortus Brucella melitensis brucellosis cell infiltration clinical feature cognitive defect computer assisted tomography cytokine release electroencephalography encephalitis enzyme linked immunosorbent assay histopathology human impaired glucose tolerance innate immunity intracellular bacterium metagenomics myelooptic neuropathy neurology neuropsychological test nonhuman nuclear magnetic resonance imaging pathogenesis pleocytosis public health risk factor sensitivity and specificity somatosensory evoked potential |
Publisher: | Humana Press Inc. | Abstract: | Brucellosis is one of the most common zoonotic infections in many parts of the world including the Mediterranean countries and Middle East, Central Asia, India, Central and South America (Gul HC, Erdem H. Brucellosis (Brucella species). In: Bennett JE, Dolin R, Blaser MJ (eds) Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. Elsevier Saunders, Philadelphi, pp 2584–2589, 2015; Pappas et al. N Engl J Med 352:2325–2336, 2005). Brucellosis is caused by the bacterial genus Brucella. Brucella is a small gram- negative, non motile and facultative intracellular bacterium. Among the Brucella species (spp.), B. melitensis, B. abortus, B. suis, and B. canis are the most common causative agents of brucellosis in humans (Franco et al. Lancet Infect Dis 7:775–786, 2007). In neurobrucellosis (NB), the most commonly B. melitensis and B. abortus and less commonly B. suis are the causative species (Wallach et al. Eur J Clin Microbiol Infect Dis 21:760–762, 2002; Kutlu et al. J Infect Public Health 9:675–678, 2016). B. ceti and B. pinnipedialis which were isolated from marine mammals, were reported as the responsible agents of intracranial granuloma formation (Sohn et al. Emerg Infect Dis 9:485–488, 2003). B. neotomae was reported to be isolated from cerebrospinal fluid samples from two patients with NB (Suárez-Esquivel et al. Emerg Infect Dis 23:997–1000, 2017). Although there are few studies about the effect of different species in the pathogenesis of the human brucellosis (Dokuzoğuz et al. J Infect 50:41–5, 2005; Troy et al. Medicine (Baltimore) 84:174–187, 2005) virulence and neurotropisim of B. melitensis are considered to be higher than the other species. © 2021, Springer Nature Switzerland AG. | URI: | https://doi.org/10.1007/978-3-030-56084-3_5 https://hdl.handle.net/11499/47331 |
ISSN: | 1559-0585 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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