Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47366
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dc.contributor.authorKutlu M.-
dc.contributor.authorSayın-Kutlu S.-
dc.contributor.authorAlp-Çavuş S.-
dc.contributor.authorÖztürk Ş.B.-
dc.contributor.authorTaşbakan M.-
dc.contributor.authorÖzhak B.-
dc.contributor.authorKaya O.-
dc.contributor.authorErgin, Cagri-
dc.date.accessioned2023-01-09T21:24:10Z-
dc.date.available2023-01-09T21:24:10Z-
dc.date.issued2022-
dc.identifier.issn0934-9723-
dc.identifier.urihttps://doi.org/10.1007/s10096-021-04394-0-
dc.identifier.urihttps://hdl.handle.net/11499/47366-
dc.description.abstractCandidemia may present as severe and life-threatening infections and is associated with a high mortality rate. This study aimed to evaluate the risk factors associated with 30-day mortality in patients with candidemia. A multi-center prospective observational study was conducted in seven university hospitals in six provinces in the western part of Turkey. Patient data were collected with a structured form between January 2018 and April 2019. In total, 425 episodes of candidemia were observed during the study period. Two hundred forty-one patients died within 30 days, and the 30-day crude mortality rate was 56.7%. Multivariable analysis found that SOFA score (OR: 1.28, CI: 1.154–1.420, p < 0.001), parenteral nutrition (OR: 3.9, CI: 1.752–8.810, p = 0.001), previous antibacterial treatment (OR: 9.32, CI: 1.634–53.744, p = 0.012), newly developed renal failure after candidemia (OR: 2.7, CI: 1.079–6.761, p = 0.034), and newly developed thrombocytopenia after candidemia (OR: 2.6, CI: 1. 057–6.439, p = 0.038) were significantly associated with 30-day mortality. Central venous catheter removal was the only factor protective against mortality (OR: 0.34, CI:0.147–0.768, p = 0.010) in multivariable analysis. Candidemia mortality is high in patients with high SOFA scores, those receiving TPN therapy, and those who previously received antibacterial therapy. Renal failure and thrombocytopenia developing after candidemia should be followed carefully in patients. Antifungal therapy and removing the central venous catheter are essential in the management of candidemia. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology and Infectious Diseasesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCandidaen_US
dc.subjectCandida parapsilosisen_US
dc.subjectCatheter removalen_US
dc.subjectMortalityen_US
dc.subjectRisk factorsen_US
dc.subjectamphotericin Ben_US
dc.subjectamphotericin B lipid complexen_US
dc.subjectanidulafunginen_US
dc.subjectantibiotic agenten_US
dc.subjectantifungal agenten_US
dc.subjectcaspofunginen_US
dc.subjectechinocandinen_US
dc.subjectfluconazoleen_US
dc.subjectitraconazoleen_US
dc.subjectmicafunginen_US
dc.subjectposaconazoleen_US
dc.subjectprednisoloneen_US
dc.subjectvoriconazoleen_US
dc.subjectantifungal agenten_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectantibiotic therapyen_US
dc.subjectantifungal susceptibilityen_US
dc.subjectantifungal therapyen_US
dc.subjectArticleen_US
dc.subjectbacteremiaen_US
dc.subjectCandidaen_US
dc.subjectCandida albicansen_US
dc.subjectCandida endocarditisen_US
dc.subjectCandida endophthalmitisen_US
dc.subjectCandida parapsilosisen_US
dc.subjectcandidemiaen_US
dc.subjectcandidiasisen_US
dc.subjectcatheter removalen_US
dc.subjectcohort analysisen_US
dc.subjectcontrolled studyen_US
dc.subjectcorticosteroid therapyen_US
dc.subjectcrude mortality rateen_US
dc.subjectdata collection methoden_US
dc.subjectdrug substitutionen_US
dc.subjectdrug withdrawalen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectkidney failureen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmortalityen_US
dc.subjectmulticenter studyen_US
dc.subjectneutropeniaen_US
dc.subjectobservational studyen_US
dc.subjectodds ratioen_US
dc.subjectparenteral nutritionen_US
dc.subjectpatient codingen_US
dc.subjectprospective studyen_US
dc.subjectrisk factoren_US
dc.subjectSequential Organ Failure Assessment Scoreen_US
dc.subjectthrombocytopeniaen_US
dc.subjectTurkey (republic)en_US
dc.subjectuniversity hospitalen_US
dc.subjectunspecified side effecten_US
dc.subjectcandidemiaen_US
dc.subjectclinical trialen_US
dc.subjectmicrobiologyen_US
dc.subjectretrospective studyen_US
dc.subjectturkey (bird)en_US
dc.subjectAntifungal Agentsen_US
dc.subjectCandidaen_US
dc.subjectCandidemiaen_US
dc.subjectHumansen_US
dc.subjectProspective Studiesen_US
dc.subjectRetrospective Studiesen_US
dc.subjectRisk Factorsen_US
dc.subjectTurkeyen_US
dc.titleMortality-associated factors of candidemia: a multi-center prospective cohort in Turkeyen_US
dc.typeArticleen_US
dc.identifier.volume41en_US
dc.identifier.issue4en_US
dc.identifier.startpage597en_US
dc.identifier.endpage607en_US
dc.identifier.doi10.1007/s10096-021-04394-0-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid6603843040-
dc.authorscopusid6506439433-
dc.authorscopusid12783463800-
dc.authorscopusid56313019000-
dc.authorscopusid55664567200-
dc.authorscopusid21743795100-
dc.authorscopusid36116637700-
dc.identifier.pmid35083558en_US
dc.identifier.scopus2-s2.0-85123593534en_US
dc.identifier.wosWOS:000749138700001en_US
dc.identifier.scopusqualityQ1-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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