Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47388
Title: Can PET/CT be used more effectively in pleural effusion evaluation?
Authors: Şimsek, Fikri Selçuk
Yüksel, Doğangün
Yaylalı, Olga
Aslan, Halil Serdar
Kılıçarslan, Emel
Bir, Ferda
Arslan, Muhammet
Can, Fatma Ezgi
Uğurlu, Erhan
Keywords: 18F-FDG-PET
Combined approaches
CT
Pleural effusion
fluorodeoxyglucose f 18
radiopharmaceutical agent
diagnostic imaging
human
multiple pulmonary nodules
pleura effusion
positron emission tomography-computed tomography
tumor recurrence
Fluorodeoxyglucose F18
Humans
Multiple Pulmonary Nodules
Neoplasm Recurrence, Local
Pleural Effusion
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
Publisher: Springer Japan
Abstract: Purpose: Sometimes, characterization of pleural effusion (PE) can be challenging especially in patients whom invasive procedures/recurrent invasive procedures cannot be performed. The main purpose of the study is to answer this question, Can 18F-FDG-PET/CT contribute to reduction in the number of invasive procedures or patients undergoing to invasive procedures? Results may increase the effectiveness of patient management by facilitating clinical decision-making, especially in patients who cannot undergo invasive/recurrent invasive procedures. Methods: Sixty-seven patients’ 18F-FDG-PET/CT, pleural fluid cytologies (PFCs) and, if any, pleural biopsies were re-assessed. If patient’s PFC/biopsy was malignant, effusion was considered as malignant. If two consecutive PFCs were negative in patients without biopsy, effusion was considered as benign. Characterization was based on consensus with baseline/follow-up 18F-FDG-PET/CT and clinical parameters in patients with one negative PFC (n = 6). Results: None of the 18F-FDG-PET/CT parameters could characterize PE alone. However, if PE maximum standardized uptake value (SUVmax) > 1.3 or PE SUVmax/mean standardized uptake value of mediastinal blood pool (MBP SUVmean) > 1.2 was combined with at least one of the following, specificity and positive predictive value (PPV) were 100%, accuracy was around 90%. Diffuse-nodular/nodular pleural thickness, post-obstructive atelectasis, nodule/mass with SUVmax > 2.5 in lung, multiple pulmonary nodules. All 29 patients who had SUVmax > 1.3 together with at least one of the mentioned four parameters diagnosed malignant pleural effusion (MPE). However, sensitivity and negative predictive value (NPV) were still insufficient. Conclusion: Patients who have contraindications for invasive diagnostic methods, and meet the aforementioned criteria may be considered as MPE primarily. On the other hand, if PE SUVmax < 1.3 or PE SUVmax/MBP SUVmean < 1.2 with the negativity of the all four parameters mentioned above, it is difficult to say that this can be considered as benign pleural effusion (BPE) according to our results. © 2021, Japan Radiological Society.
URI: https://doi.org/10.1007/s11604-021-01155-z
https://hdl.handle.net/11499/47388
ISSN: 1867-1071
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

Show full item record



CORE Recommender

SCOPUSTM   
Citations

2
checked on Jun 1, 2024

Page view(s)

58
checked on May 27, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.