Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4739
Title: Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth factor I, and insulin-like growth factor-binding protein 3
Authors: Turgut, Sebahat
Kaptanoglu, Bünyamin
Turgut, Günfer
Emmungil, Gülten
Genç, Osman
Keywords: Cadmium
Growth hormone
IGF-I
IGFBP-3
Insulin-like growth factor binding protein 3
Insulin-like growth factor I
Zinc
cadmium
drinking water
growth hormone
somatomedin binding protein 3
somatomedin C
zinc
animal experiment
article
blood sampling
cadmium blood level
controlled study
diet supplementation
growth hormone blood level
growth hormone release
hormone blood level
hormone determination
male
nonhuman
protein blood level
rank sum test
rat
species comparison
trace metal blood level
zinc blood level
Animals
Growth Hormone
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Male
Rats
Rats, Wistar
Animalia
Abstract: Humans are constantly exposed to cadmium (Cd) as a result of the increase in air pollution and cigaret use. Zinc (Zn), which is an essential element for the metabolism of and the constituent of many enzymes, causes growth retardation in the deficiency status, so at present it is often added to the diet without measuring blood levels of this element. We also aimed to observe the effects of both Cd and Zn on the plasma levels of growth hormone (GH), insulin-like growth factor I (IGF-I), and insulin-like growth factor-binding protein 3 (IGFBP-3) in this study. For this purpose, 27 young Wistar albino male rats were divided into three groups. The first group was given 50 mg/L of CdCl2, the second group received 500 mg/L of ZnSO4, and the third group, as a control, received only drinking water for 1 mo. At the end of this period, plasma GH, IGF-I, and IGFBP-3 of the animals were analyzed in the blood obtained. The significance between groups was evaluated with the Mann-Whitney U-test. According to our results, levels of IGF-I and IGFBP-3 in the Cd-administered group were significantly lower than those of controls (p<0.05 and p<0.01 respectively). No statistically significant difference was observed between Zn-administered and control groups in terms of all three parameters. These results show that although the addition of Zn to the diet of healthy rats had no effect on the levels of GH, IGF-I, and IGFBP-3, Cd addition lowered the levels of IGF-I and IGFBP-3 but did not change the levels of GH compared to controls. © Copyright 2005 by Humana Press Inc. All rights of any nature, whatsoever, reserved.
URI: https://hdl.handle.net/11499/4739
https://doi.org/10.1385/BTER:108:1-3:197
ISSN: 0163-4984
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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