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https://hdl.handle.net/11499/4739
Title: | Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth factor I, and insulin-like growth factor-binding protein 3 | Authors: | Turgut, Sebahat Kaptanoglu, Bünyamin Turgut, Günfer Emmungil, Gülten Genç, Osman |
Keywords: | Cadmium Growth hormone IGF-I IGFBP-3 Insulin-like growth factor binding protein 3 Insulin-like growth factor I Zinc cadmium drinking water growth hormone somatomedin binding protein 3 somatomedin C zinc animal experiment article blood sampling cadmium blood level controlled study diet supplementation growth hormone blood level growth hormone release hormone blood level hormone determination male nonhuman protein blood level rank sum test rat species comparison trace metal blood level zinc blood level Animals Growth Hormone Humans Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Male Rats Rats, Wistar Animalia |
Abstract: | Humans are constantly exposed to cadmium (Cd) as a result of the increase in air pollution and cigaret use. Zinc (Zn), which is an essential element for the metabolism of and the constituent of many enzymes, causes growth retardation in the deficiency status, so at present it is often added to the diet without measuring blood levels of this element. We also aimed to observe the effects of both Cd and Zn on the plasma levels of growth hormone (GH), insulin-like growth factor I (IGF-I), and insulin-like growth factor-binding protein 3 (IGFBP-3) in this study. For this purpose, 27 young Wistar albino male rats were divided into three groups. The first group was given 50 mg/L of CdCl2, the second group received 500 mg/L of ZnSO4, and the third group, as a control, received only drinking water for 1 mo. At the end of this period, plasma GH, IGF-I, and IGFBP-3 of the animals were analyzed in the blood obtained. The significance between groups was evaluated with the Mann-Whitney U-test. According to our results, levels of IGF-I and IGFBP-3 in the Cd-administered group were significantly lower than those of controls (p<0.05 and p<0.01 respectively). No statistically significant difference was observed between Zn-administered and control groups in terms of all three parameters. These results show that although the addition of Zn to the diet of healthy rats had no effect on the levels of GH, IGF-I, and IGFBP-3, Cd addition lowered the levels of IGF-I and IGFBP-3 but did not change the levels of GH compared to controls. © Copyright 2005 by Humana Press Inc. All rights of any nature, whatsoever, reserved. | URI: | https://hdl.handle.net/11499/4739 https://doi.org/10.1385/BTER:108:1-3:197 |
ISSN: | 0163-4984 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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