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https://hdl.handle.net/11499/47468
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DC Field | Value | Language |
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dc.contributor.author | Karslı, Emre | - |
dc.contributor.author | Sabırlı, Ramazan | - |
dc.contributor.author | Altıntaş, Emel | - |
dc.contributor.author | Canaçık, Ömer | - |
dc.contributor.author | Tükenmez Sabırlı, Gizem | - |
dc.contributor.author | Kaymaz, Buse | - |
dc.contributor.author | Kurt, Özgür | - |
dc.contributor.author | Köseler, Aylin | - |
dc.date.accessioned | 2023-01-09T21:24:50Z | - |
dc.date.available | 2023-01-09T21:24:50Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | https://doi.org/10.1016/j.lfs.2021.119634 | - |
dc.identifier.uri | https://hdl.handle.net/11499/47468 | - |
dc.description.abstract | Introduction: To our knowledge, the diagnostic value of the sP-Selectin level in the diagnosis of COVID-19 disease has not yet been investigated. In this study, we aimed to assess this by evaluating the relationship between sP-Selectin level and the clinical severity of COVID-19 infections. Methods: A total of 80 patients (50 with mild to moderate and 30 with severe COVID-19 pneumonia), and 60 non-symptomatic healthy volunteers participated in the study. Following serum isolation, sP-Selectin levels were assessed by Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: The serum sP-Selectin level was 1.7 ng/ml in the control group (1–3.78); 6.24 ng/ml (5.14–7.23) in mild-to-moderate pneumonia group; and 6.72 ng/ml (5.36–8.03) in the severe pneumonia group. Serum sP-Selectin levels in both mild-to-moderate pneumonia and severe pneumonia groups were found to be higher than the control group, with statistical significance (p = 0.0001 and p = 0.0001, respectively). Receiver operating characteristic analysis (ROC) showed greater area under the curve (AUC) for the serum sP-Selectin levels of the COVID-19 patients (AUC = 0.913, 95% CI = 0.857–0.969; p = 0.0001). The serum sP-Selectin level was found to be 97.5% sensitive and 80% specific at 4.125 ng/ml level for diagnosis (p = 0.0001). The serum sP-Selectin level was found to be 76.9% sensitive and 51.9% specific at the level of 6.12 ng/ml (p = 0.005) to predict the need for intensive care treatment. Conclusion: This study showed that sP-Selectin can be used as a valuable biomarker in both diagnosing and predicting the need for intensive care treatment of COVID-19 infection. © 2021 | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Inc. | en_US |
dc.relation.ispartof | Life Sciences | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | COVID-19 infection | en_US |
dc.subject | Pneumonia | en_US |
dc.subject | Serum soluble P-selectin levels | en_US |
dc.subject | alanine aminotransferase | en_US |
dc.subject | aspartate aminotransferase | en_US |
dc.subject | bicarbonate | en_US |
dc.subject | bilirubin | en_US |
dc.subject | C reactive protein | en_US |
dc.subject | carbon dioxide | en_US |
dc.subject | creatine kinase MB | en_US |
dc.subject | creatinine | en_US |
dc.subject | D dimer | en_US |
dc.subject | lactic acid | en_US |
dc.subject | oxygen | en_US |
dc.subject | PADGEM protein | en_US |
dc.subject | troponin T | en_US |
dc.subject | urea | en_US |
dc.subject | biological marker | en_US |
dc.subject | PADGEM protein | en_US |
dc.subject | area under the curve | en_US |
dc.subject | Article | en_US |
dc.subject | blood analysis | en_US |
dc.subject | blood level | en_US |
dc.subject | case control study | en_US |
dc.subject | comorbidity | en_US |
dc.subject | controlled study | en_US |
dc.subject | coronary artery disease | en_US |
dc.subject | coronavirus disease 2019 | en_US |
dc.subject | CURB-65 score | en_US |
dc.subject | diabetes mellitus | en_US |
dc.subject | diagnostic test accuracy study | en_US |
dc.subject | diagnostic value | en_US |
dc.subject | diastolic blood pressure | en_US |
dc.subject | disease association | en_US |
dc.subject | disease duration | en_US |
dc.subject | disease marker | en_US |
dc.subject | disease severity | en_US |
dc.subject | enzyme linked immunosorbent assay | en_US |
dc.subject | erythrocyte sedimentation rate | en_US |
dc.subject | fever | en_US |
dc.subject | heart rate | en_US |
dc.subject | human | en_US |
dc.subject | hyperlipidemia | en_US |
dc.subject | hypertension | en_US |
dc.subject | intensive care unit | en_US |
dc.subject | major clinical study | en_US |
dc.subject | oxygen saturation | en_US |
dc.subject | prediction | en_US |
dc.subject | prognosis | en_US |
dc.subject | receiver operating characteristic | en_US |
dc.subject | sensitivity and specificity | en_US |
dc.subject | systolic blood pressure | en_US |
dc.subject | virus pneumonia | en_US |
dc.subject | blood | en_US |
dc.subject | diagnosis | en_US |
dc.subject | female | en_US |
dc.subject | isolation and purification | en_US |
dc.subject | male | en_US |
dc.subject | prognosis | en_US |
dc.subject | prospective study | en_US |
dc.subject | severity of illness index | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Case-Control Studies | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | P-Selectin | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Prospective Studies | en_US |
dc.subject | ROC Curve | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Severity of Illness Index | en_US |
dc.title | Soluble P-selectin as a potential diagnostic and prognostic biomarker for COVID-19 disease: A case-control study | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 277 | en_US |
dc.identifier.doi | 10.1016/j.lfs.2021.119634 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57189897004 | - |
dc.authorscopusid | 57203260655 | - |
dc.authorscopusid | 57192676165 | - |
dc.authorscopusid | 57189893421 | - |
dc.authorscopusid | 57210885478 | - |
dc.authorscopusid | 57223866198 | - |
dc.authorscopusid | 6602818486 | - |
dc.identifier.pmid | 34015287 | en_US |
dc.identifier.scopus | 2-s2.0-85106251378 | en_US |
dc.identifier.scopusquality | Q1 | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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