Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47480
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dc.contributor.authorAkaslan Kara A.-
dc.contributor.authorÇay Ü.-
dc.contributor.authorYalçınkaya R.-
dc.contributor.authorErdeniz E.H.-
dc.contributor.authorTural Kara T.-
dc.contributor.authorÖzdemir H.-
dc.contributor.authorGüner Özenen G.-
dc.contributor.authorPolat, Meltem-
dc.date.accessioned2023-01-09T21:24:56Z-
dc.date.available2023-01-09T21:24:56Z-
dc.date.issued2022-
dc.identifier.issn1156-5233-
dc.identifier.urihttps://doi.org/10.1016/j.mycmed.2021.101229-
dc.identifier.urihttps://hdl.handle.net/11499/47480-
dc.description.abstractBackground: Invasive Trichosporon infections are rarely seen opportunistic fungal infections in children and mainly affect immunocompromised patients. This multicenter retrospective study has rewieved the characteristics, risk factors, treatment modalities and outcomes of bloodstream infections caused by Trichosporon species in children diagnosed over the past ten years in Turkey. Methods: The study was performed with the participation of 12 of 55 hospitals invited from Turkey. In each center, the patients with bloodstream infections caused by Trichosporon spp. between January 2010 and December 2020 were retrospectively ascertained and the results were reported to the study coordinator by means of a simple case report. Data were collected on patient demographics, underlying condition(s), treatment of.infections caused by Trichosporon spp, and 7 and 30- day mortality rates. Results: A total of 28 cases with fungemia caused by Trichosporon spp. were included in the study. The most common underlying disease was paediatric cancers (39.3%). T. asahii infections were detected in 78.5 % (n=22) of patients. A various spectrum of antifungal treatment regimens were used including intravenous amphotericin B monotherapy in 35.7%, intravenous amphotericin B and voriconazole combination in 32.1% and intravenous voriconazole monotherapy in 28.6% of the patients. The overall mortality rate was 28.5 %. The mortality rates were 12.5% in the voricanozole, 30% in the amphotericin B and 33.3% in combined voriconazole -amphotericin B arms Conclusions: Invasive Trichosporon infections with an important impact of patients quality of life are almost related to underlying diseases with an overall mortality rate of 28.5%. Voriconazole was found to be associated with lower mortality rates when compared with other treatment regimens. © 2021 SFMMen_US
dc.description.sponsorshipNo potential conflict of interest has been declared by the author(s). All authors have reviewed and approved the finalized version of the manuscript, and contributed significantly to the survey. No financial support was provided relevant to this article. The manuscript has not been previously published nor is it being considered for publication elsewhereen_US
dc.language.isoenen_US
dc.publisherElsevier Masson s.r.l.en_US
dc.relation.ispartofJournal of Medical Mycologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInvasive infectionen_US
dc.subjectpaediatricen_US
dc.subjectTrichosporonen_US
dc.subjectamphotericin Ben_US
dc.subjectanidulafunginen_US
dc.subjectcaspofunginen_US
dc.subjectfluconazoleen_US
dc.subjectflucytosineen_US
dc.subjectmicafunginen_US
dc.subjectvoriconazoleen_US
dc.subjectantifungal agenten_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectchilden_US
dc.subjectchildhood canceren_US
dc.subjectclinical outcomeen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjectfungemiaen_US
dc.subjecthumanen_US
dc.subjectinfanten_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmonotherapyen_US
dc.subjectmortality rateen_US
dc.subjectpediatricsen_US
dc.subjectretrospective studyen_US
dc.subjectrisk factoren_US
dc.subjectTrichosporonen_US
dc.subjecttrichosporonosisen_US
dc.subjectturkey (bird)en_US
dc.subjectTurkey (republic)en_US
dc.subjectcase reporten_US
dc.subjectclinical trialen_US
dc.subjectepidemiologyen_US
dc.subjectmulticenter studyen_US
dc.subjectquality of lifeen_US
dc.subjectsepsisen_US
dc.subjectTrichosporonen_US
dc.subjectAntifungal Agentsen_US
dc.subjectChilden_US
dc.subjectHumansen_US
dc.subjectQuality of Lifeen_US
dc.subjectRetrospective Studiesen_US
dc.subjectSepsisen_US
dc.subjectTrichosporonen_US
dc.subjectTurkeyen_US
dc.titleBloodstream infections due to Trichosporon species in paediatric patients: Results from the first national study from Turkeyen_US
dc.typeArticleen_US
dc.identifier.volume32en_US
dc.identifier.issue1en_US
dc.identifier.doi10.1016/j.mycmed.2021.101229-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid56801039500-
dc.authorscopusid57190486762-
dc.authorscopusid57039902500-
dc.authorscopusid56177424100-
dc.authorscopusid56913066300-
dc.authorscopusid16242021300-
dc.authorscopusid57221502271-
dc.identifier.pmid34911023en_US
dc.identifier.scopus2-s2.0-85121222817en_US
dc.identifier.wosWOS:000778276400016en_US
dc.identifier.scopusqualityQ3-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeArticle-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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