Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47490
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dc.contributor.authorSengöz T.-
dc.contributor.authorKarakaya Y.A.-
dc.contributor.authorGültekin A.-
dc.contributor.authorYaylali O.-
dc.contributor.authorSenol H.-
dc.contributor.authorYuksel D.-
dc.date.accessioned2023-01-09T21:25:00Z-
dc.date.available2023-01-09T21:25:00Z-
dc.date.issued2022-
dc.identifier.issn2253-654X-
dc.identifier.urihttps://doi.org/10.1016/j.remn.2020.11.006-
dc.identifier.urihttps://hdl.handle.net/11499/47490-
dc.description.abstractObjectives: In this study, we aimed to investigate the correlation between SUVmax of primary tumor and prognostic factors/molecular subtype in ductal breast cancer patients. Materials and methods: We retrospectively reviewed 150 female patients with pathologically proven invasive ductal breast cancer from January 2015 to October 2019 who underwent 18F-FDG PET/CT for initial staging. Histopathological prognostic features of the primary tumor (histological grade, hormone receptor status, Ki-67 index, vb.) were obtained from the tru-cut biopsy report. In 18F-FDG PET/CT studies, the maximum standardized uptake value (SUVmax) of the primary breast tumor was calculated and compared with the presence of axillary lymphadenopathy and/or distant metastases, histopathological prognostic factors and molecular subtype. Results: The high SUVmax of primary breast tumors is significantly correlated with the clinicopathological factors: high tumor size, high histologic grade, high Ki-67 index, axillary lymph node positivity and distant metastasis. SUVmax value was significantly higher in patients with basal subtype than patients with Luminal A subtype (8.14 ± 3.71 and 4.64 ± 2.45, p = 0.002). Correlation analysis revealed a low correlation between Ki-67 index and SUVmax (r = 0.276, p = 0.001) and moderate correlation between tumor size and SUVmax (r = 0.470, p = 0.001). In multivariate linear regression analysis, Ki-67 index and tumor size had a statistically significant effect on SUVmax values. As these parameters increase, it is seen that it increases SUVmax values (p = 0.004, Std Beta: 0.228, 95% CI: 0.010–0.055 and p = 0.001, Std Beta: 0.374, 95% CI: 0.55–0.136, respectively). Conclusión: High SUVmax value is associated with prognotic factors suggesting poor prognosis. Pretreatment 18F-FDG PET/CT can be used as a tool to predict prognosis in breast cancer. © 2021 Sociedad Española de Medicina Nuclear e Imagen Molecularen_US
dc.language.isoenen_US
dc.publisherEdiciones Doyma, S.L.en_US
dc.relation.ispartofRevista Espanola de Medicina Nuclear e Imagen Molecularen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject18F-FDGen_US
dc.subjectDuctal breast canceren_US
dc.subjectMolecular subtypeen_US
dc.subjectp53en_US
dc.subjectSUVmaxen_US
dc.subjectfluorodeoxyglucose f 18en_US
dc.subjecthormone receptoren_US
dc.subjectKi 67 antigenen_US
dc.subjectArticleen_US
dc.subjectaxillary lymph nodeen_US
dc.subjectaxillary lymphadenopathyen_US
dc.subjectbasal subtype breast canceren_US
dc.subjectbreast canceren_US
dc.subjectbreast cancer molecular subtypeen_US
dc.subjectcancer gradingen_US
dc.subjectcancer patienten_US
dc.subjectcancer prognosisen_US
dc.subjectcancer stagingen_US
dc.subjectcorrelational studyen_US
dc.subjectdistant metastasisen_US
dc.subjectfemaleen_US
dc.subjecthistopathologyen_US
dc.subjecthumanen_US
dc.subjectinvasive ductal breast carcinomaen_US
dc.subjectluminal A breast canceren_US
dc.subjectlymphadenopathyen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaximum standardized uptake valueen_US
dc.subjectpositron emission tomography-computed tomographyen_US
dc.subjectpredictionen_US
dc.subjectprimary tumoren_US
dc.subjectretrospective studyen_US
dc.subjecttumor volumeen_US
dc.subjectbreast tumoren_US
dc.subjectdiagnostic imagingen_US
dc.subjectprognosisen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectFemaleen_US
dc.subjectFluorodeoxyglucose F18en_US
dc.subjectHumansen_US
dc.subjectPositron Emission Tomography Computed Tomographyen_US
dc.subjectPrognosisen_US
dc.subjectRetrospective Studiesen_US
dc.titleRelationships of 18F-FDG uptake by primary tumors with prognostic factors and molecular subtype in ductal breast canceren_US
dc.title.alternativeCorrelación entre la captación de 18F-FDG del tumor primario con los factores pronósticos y subtipo molecular del cáncer ductal de mamaen_US
dc.typeArticleen_US
dc.identifier.volume41en_US
dc.identifier.issue1en_US
dc.identifier.startpage32en_US
dc.identifier.endpage38en_US
dc.identifier.doi10.1016/j.remn.2020.11.006-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid56667569600-
dc.authorscopusid56464098200-
dc.authorscopusid57213854346-
dc.authorscopusid23135840600-
dc.authorscopusid56345836900-
dc.authorscopusid6701446280-
dc.identifier.pmid34991834en_US
dc.identifier.scopus2-s2.0-85123270219en_US
dc.identifier.wosWOS:000741424000005en_US
dc.identifier.scopusqualityQ3-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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