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https://hdl.handle.net/11499/47490
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DC Field | Value | Language |
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dc.contributor.author | Sengöz T. | - |
dc.contributor.author | Karakaya Y.A. | - |
dc.contributor.author | Gültekin A. | - |
dc.contributor.author | Yaylali O. | - |
dc.contributor.author | Senol H. | - |
dc.contributor.author | Yuksel D. | - |
dc.date.accessioned | 2023-01-09T21:25:00Z | - |
dc.date.available | 2023-01-09T21:25:00Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2253-654X | - |
dc.identifier.uri | https://doi.org/10.1016/j.remn.2020.11.006 | - |
dc.identifier.uri | https://hdl.handle.net/11499/47490 | - |
dc.description.abstract | Objectives: In this study, we aimed to investigate the correlation between SUVmax of primary tumor and prognostic factors/molecular subtype in ductal breast cancer patients. Materials and methods: We retrospectively reviewed 150 female patients with pathologically proven invasive ductal breast cancer from January 2015 to October 2019 who underwent 18F-FDG PET/CT for initial staging. Histopathological prognostic features of the primary tumor (histological grade, hormone receptor status, Ki-67 index, vb.) were obtained from the tru-cut biopsy report. In 18F-FDG PET/CT studies, the maximum standardized uptake value (SUVmax) of the primary breast tumor was calculated and compared with the presence of axillary lymphadenopathy and/or distant metastases, histopathological prognostic factors and molecular subtype. Results: The high SUVmax of primary breast tumors is significantly correlated with the clinicopathological factors: high tumor size, high histologic grade, high Ki-67 index, axillary lymph node positivity and distant metastasis. SUVmax value was significantly higher in patients with basal subtype than patients with Luminal A subtype (8.14 ± 3.71 and 4.64 ± 2.45, p = 0.002). Correlation analysis revealed a low correlation between Ki-67 index and SUVmax (r = 0.276, p = 0.001) and moderate correlation between tumor size and SUVmax (r = 0.470, p = 0.001). In multivariate linear regression analysis, Ki-67 index and tumor size had a statistically significant effect on SUVmax values. As these parameters increase, it is seen that it increases SUVmax values (p = 0.004, Std Beta: 0.228, 95% CI: 0.010–0.055 and p = 0.001, Std Beta: 0.374, 95% CI: 0.55–0.136, respectively). Conclusión: High SUVmax value is associated with prognotic factors suggesting poor prognosis. Pretreatment 18F-FDG PET/CT can be used as a tool to predict prognosis in breast cancer. © 2021 Sociedad Española de Medicina Nuclear e Imagen Molecular | en_US |
dc.language.iso | en | en_US |
dc.publisher | Ediciones Doyma, S.L. | en_US |
dc.relation.ispartof | Revista Espanola de Medicina Nuclear e Imagen Molecular | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 18F-FDG | en_US |
dc.subject | Ductal breast cancer | en_US |
dc.subject | Molecular subtype | en_US |
dc.subject | p53 | en_US |
dc.subject | SUVmax | en_US |
dc.subject | fluorodeoxyglucose f 18 | en_US |
dc.subject | hormone receptor | en_US |
dc.subject | Ki 67 antigen | en_US |
dc.subject | Article | en_US |
dc.subject | axillary lymph node | en_US |
dc.subject | axillary lymphadenopathy | en_US |
dc.subject | basal subtype breast cancer | en_US |
dc.subject | breast cancer | en_US |
dc.subject | breast cancer molecular subtype | en_US |
dc.subject | cancer grading | en_US |
dc.subject | cancer patient | en_US |
dc.subject | cancer prognosis | en_US |
dc.subject | cancer staging | en_US |
dc.subject | correlational study | en_US |
dc.subject | distant metastasis | en_US |
dc.subject | female | en_US |
dc.subject | histopathology | en_US |
dc.subject | human | en_US |
dc.subject | invasive ductal breast carcinoma | en_US |
dc.subject | luminal A breast cancer | en_US |
dc.subject | lymphadenopathy | en_US |
dc.subject | major clinical study | en_US |
dc.subject | maximum standardized uptake value | en_US |
dc.subject | positron emission tomography-computed tomography | en_US |
dc.subject | prediction | en_US |
dc.subject | primary tumor | en_US |
dc.subject | retrospective study | en_US |
dc.subject | tumor volume | en_US |
dc.subject | breast tumor | en_US |
dc.subject | diagnostic imaging | en_US |
dc.subject | prognosis | en_US |
dc.subject | Breast Neoplasms | en_US |
dc.subject | Female | en_US |
dc.subject | Fluorodeoxyglucose F18 | en_US |
dc.subject | Humans | en_US |
dc.subject | Positron Emission Tomography Computed Tomography | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Retrospective Studies | en_US |
dc.title | Relationships of 18F-FDG uptake by primary tumors with prognostic factors and molecular subtype in ductal breast cancer | en_US |
dc.title.alternative | Correlación entre la captación de 18F-FDG del tumor primario con los factores pronósticos y subtipo molecular del cáncer ductal de mama | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 41 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 32 | en_US |
dc.identifier.endpage | 38 | en_US |
dc.identifier.doi | 10.1016/j.remn.2020.11.006 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56667569600 | - |
dc.authorscopusid | 56464098200 | - |
dc.authorscopusid | 57213854346 | - |
dc.authorscopusid | 23135840600 | - |
dc.authorscopusid | 56345836900 | - |
dc.authorscopusid | 6701446280 | - |
dc.identifier.pmid | 34991834 | en_US |
dc.identifier.scopus | 2-s2.0-85123270219 | en_US |
dc.identifier.wos | WOS:000741424000005 | en_US |
dc.identifier.scopusquality | Q3 | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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