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https://hdl.handle.net/11499/47494
Title: | Correlates of psychotic like experiences (PLEs) during Pandemic: An online study investigating a possible link between the SARS-CoV-2 infection and PLEs among adolescents | Authors: | Yılmaz Kafalı, Helin Turan, Serkan Akpınar, Serap Mutlu, Müge Özkaya Parlakay, Aslınur Çöp, Esra Toulopoulou, Timothea . |
Keywords: | Adolescence Pandemic Psychiatry Psychotic like experiences SARS-CoV-2 C reactive protein adolescent adult alcohol consumption anxiety disorder Article child cigarette smoking Community Assessment of Psychic Experiences 42 Positive Dimension comparative study controlled study coronavirus disease 2019 correlational study depression disease association drug use female Generalized Anxiety Disorder-7 groups by age human human cell internalizing disorder major clinical study male monocyte count online system pandemic Patient Health Questionnaire 9 Pittsburg Sleep Quality Index questionnaire psychosis questionnaire scoring system sleep disorder volunteer pandemic prospective study psychosis Adolescent Child COVID-19 Humans Pandemics Prospective Studies Psychotic Disorders SARS-CoV-2 Surveys and Questionnaires |
Publisher: | Elsevier B.V. | Abstract: | Background: This study investigated whether SARS-CoV-2 infection, depression, anxiety, sleep problems, cigarette, alcohol, drug usage contribute to psychotic-like experiences (PLEs) among adolescents during the pandemic. We also aimed to explore whether baseline inflammatory markers or the number of SARS-CoV-2-related symptoms are associated with PLEs, and the latter is mediated by internalizing symptoms. Methods: Altogether, 684 adolescents aged 12–18 (SARS-CoV-2 group n = 361, control group (CG) n = 323) were recruited. The Community Assessment of Psychic Experiences-42-Positive Dimension (CAPE-Pos), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Pittsburg Sleep Quality Index (PSQI) questionnaires were completed by all volunteers using an online survey. C-reactive Protein and hemogram values, and SARS-CoV-2-related symptoms during the acute infection period were recorded in the SARS-CoV-2 group. Group comparisons, correlations, logistic regression, and bootstrapped mediation analyses were performed. Results: CAPE-Pos-Frequency/Stress scores were significantly higher, whereas GAD-7-Total and PSQI-Total scores were significantly lower in SARS-CoV-2 than CG. Among the SARS-CoV-2 group, monocyte count and the number of SARS-CoV-2-symptoms were positively correlated with CAPE-Pos-Frequency/Stress scores. Besides SARS-CoV-2, cigarette use, GAD-7, and PHQ-9 scores significantly contributed to the presence of at least one CAPE-Pos “often” or “almost always”. PHQ-9 and GAD-7 fully mediated the relationship between the number of SARS-CoV-2 symptoms and CAPE-Pos-Frequency. Conclusions: This study is the first to show a possible relationship between SARS-CoV-2 infection and PLEs among adolescents. Depression, anxiety, and cigarette use also contributed to PLEs. The number of SARS-Cov-2-symptoms and PLEs association was fully mediated by internalizing symptoms, but prospective studies will need to confirm this result. © 2021 | URI: | https://doi.org/10.1016/j.schres.2021.12.049 https://hdl.handle.net/11499/47494 |
ISSN: | 0920-9964 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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