Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47494
Title: Correlates of psychotic like experiences (PLEs) during Pandemic: An online study investigating a possible link between the SARS-CoV-2 infection and PLEs among adolescents
Authors: Yılmaz Kafalı, Helin
Turan, Serkan
Akpınar, Serap
Mutlu, Müge
Özkaya Parlakay, Aslınur
Çöp, Esra
Toulopoulou, Timothea .
Keywords: Adolescence
Pandemic
Psychiatry
Psychotic like experiences
SARS-CoV-2
C reactive protein
adolescent
adult
alcohol consumption
anxiety disorder
Article
child
cigarette smoking
Community Assessment of Psychic Experiences 42 Positive Dimension
comparative study
controlled study
coronavirus disease 2019
correlational study
depression
disease association
drug use
female
Generalized Anxiety Disorder-7
groups by age
human
human cell
internalizing disorder
major clinical study
male
monocyte count
online system
pandemic
Patient Health Questionnaire 9
Pittsburg Sleep Quality Index questionnaire
psychosis
questionnaire
scoring system
sleep disorder
volunteer
pandemic
prospective study
psychosis
Adolescent
Child
COVID-19
Humans
Pandemics
Prospective Studies
Psychotic Disorders
SARS-CoV-2
Surveys and Questionnaires
Publisher: Elsevier B.V.
Abstract: Background: This study investigated whether SARS-CoV-2 infection, depression, anxiety, sleep problems, cigarette, alcohol, drug usage contribute to psychotic-like experiences (PLEs) among adolescents during the pandemic. We also aimed to explore whether baseline inflammatory markers or the number of SARS-CoV-2-related symptoms are associated with PLEs, and the latter is mediated by internalizing symptoms. Methods: Altogether, 684 adolescents aged 12–18 (SARS-CoV-2 group n = 361, control group (CG) n = 323) were recruited. The Community Assessment of Psychic Experiences-42-Positive Dimension (CAPE-Pos), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Pittsburg Sleep Quality Index (PSQI) questionnaires were completed by all volunteers using an online survey. C-reactive Protein and hemogram values, and SARS-CoV-2-related symptoms during the acute infection period were recorded in the SARS-CoV-2 group. Group comparisons, correlations, logistic regression, and bootstrapped mediation analyses were performed. Results: CAPE-Pos-Frequency/Stress scores were significantly higher, whereas GAD-7-Total and PSQI-Total scores were significantly lower in SARS-CoV-2 than CG. Among the SARS-CoV-2 group, monocyte count and the number of SARS-CoV-2-symptoms were positively correlated with CAPE-Pos-Frequency/Stress scores. Besides SARS-CoV-2, cigarette use, GAD-7, and PHQ-9 scores significantly contributed to the presence of at least one CAPE-Pos “often” or “almost always”. PHQ-9 and GAD-7 fully mediated the relationship between the number of SARS-CoV-2 symptoms and CAPE-Pos-Frequency. Conclusions: This study is the first to show a possible relationship between SARS-CoV-2 infection and PLEs among adolescents. Depression, anxiety, and cigarette use also contributed to PLEs. The number of SARS-Cov-2-symptoms and PLEs association was fully mediated by internalizing symptoms, but prospective studies will need to confirm this result. © 2021
URI: https://doi.org/10.1016/j.schres.2021.12.049
https://hdl.handle.net/11499/47494
ISSN: 0920-9964
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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