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https://hdl.handle.net/11499/47501
Title: | Swimming exercise restores damaging effects of fructose-enriched diet on the liver in rats | Authors: | Altintas F. Caliskan S. Ozmen O. Kilic-Toprak E. |
Keywords: | Caspase-3 Fructose Inflammation Liver Oxidative stress Swimming caspase 3 catalase fructose heat shock protein 70 osteoclast differentiation factor superoxide dismutase tumor necrosis factor caspase 3 fructose superoxide dismutase tumor necrosis factor animal experiment animal tissue Article cell count cell infiltration cell vacuole controlled study enzyme activity hepatitis high-fructose diet histopathology in vivo study inflammatory cell liver necrosis liver tissue male nonhuman oxidative stress protein expression rat swimming animal diet liver metabolism pathology Wistar rat Animals Caspase 3 Diet Fructose Liver Oxidative Stress Rats Rats, Wistar Superoxide Dismutase Swimming Tumor Necrosis Factor-alpha |
Publisher: | Elsevier Ltd | Abstract: | Fructose-enriched diet (FED) is increasing worldwide. The study aims to investigate oxidative, histopathological, and immunohistochemical effects of fructose-enriched diet and swimming exercise on liver tissue in rats. Wistar rats were divided into 4 groups: Group I (Control), Group II (FED), Group III (FED+Exercise), and Group IV (Control+Exercise). MDA levels and enzyme activities of SOD and CAT were measured in liver tissue. Also, histopathological and immunohistochemical examinations (caspase-3, RANKL, TNF-?, and HSP-70) were performed on the liver tissue. MDA levels and SOD activities were found to be significantly higher in Group III compared to the other groups (p < 0.05). SOD activity was found to be lower in Group II compared to Group I (p = 0.035). CAT activities did not differ significantly between groups. While degeneration was noticed in Group II, normal tissue architecture was observed in other groups. Caspase-3, RANKL, and TNF-? expressions were higher in Group II than in the other groups, while HSP-70 expression was lower (p < 0.05). Fructose-enriched diet increases oxidative damage, degeneration, inflammation, and necrosis in the liver. In addition, a fructose-enriched diet is damaging to the liver by increasing the expressions of caspase 3, TNF-?, and RANKL and decreasing the expression of HSP-70. Swimming exercise largely restores these effects. © 2022 Elsevier Ltd | URI: | https://doi.org/10.1016/j.tice.2022.101894 https://hdl.handle.net/11499/47501 |
ISSN: | 0040-8166 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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