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https://hdl.handle.net/11499/47516
Title: | Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients | Authors: | Anaforoğlu, İnan Sancak, Seda Akbaş, Emin Murat Oruk, Güzide Gonca Canat, Masum Tezcan, Kadriye Aydın Alphan Üç, Ziynet Görar, Süheyla Çavlak Duman, Gülhan Yaylalı, Guzin Fidan Yılmaz, Merve Ekiz Bilir, Betul Akbaba, Gülhan Tuna, Mazhar Müslüm Akçay, Seçkin Tüzün, Dilek Ekşi Haydardedeoğlu, Filiz Elbuken, Gülşah Yorulmaz, Göknur Çelik, Özlem Topbaş, Murat |
Keywords: | conventional treatment hypoparathyroidism quality of life treatment adherence adult anxiety clinical trial depression female human hypoparathyroidism male medication compliance middle aged multicenter study prospective study psychology quality of life turkey (bird) Adult Anxiety Depression Female Humans Hypoparathyroidism Male Medication Adherence Middle Aged Outcome Assessment, Health Care Prospective Studies Quality of Life Turkey |
Publisher: | Georg Thieme Verlag | Abstract: | Objectives This study aimed to evaluate the current situation of hypoparathyroid patients and to investigate the relationship between treatment adherence and quality of life. Study design Prospective, multicentre study. Methods Adult patients presenting with the diagnosis of hypoparathyroidism to 20 different endocrinology clinics were included. They were receiving conventional therapies for hypoparathyroidism, using calcium, active vitamin D, and magnesium. We collected data on demographic features, disease- and treatment-related information, and results of routine laboratory tests, treatment adherence, and presence of complications. Beck Depression Inventory, Beck Anxiety Inventory, and Short Form-36 quality of life assessments were administered. Results Among the 300 patients studied, 60.7 % were adherent to their treatment, and 34.1 % had complications. Anxiety and depression scores were significantly higher in non-adherent versus treatment-adherent patients (p ? 0.001 and p = 0.001, respectively). Most of the domains of quality-of-life scores were also significantly lower in non-adherent patients. Both anxiety and depression scores showed significant, negative correlations with serum calcium and magnesium concentrations (r = -0.336, p ? 0.001 and r = -0.258, p ? 0.001, respectively). Conclusions Nearly 40 % of the patients were non-adherent to conventional treatment for hypoparathyroidism, and such patients had higher anxiety and depression scores and poorer quality of life scores. Conventional treatment might not be sufficient to meet the needs of patients with hypoparathyroidism. In addition to seeking new therapeutic options, factors influencing quality of life should also be investigated and strategies to improve treatment adherence should be developed. © 2021 Georg Thieme Verlag. All rights reserved. | URI: | https://doi.org/10.1055/a-1400-2668 https://hdl.handle.net/11499/47516 |
ISSN: | 0947-7349 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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