Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47559
Title: Histopathological and Clinical Analysis of Skin Rashes in Children with Multisystem Inflammatory Syndrome Associated with COVID-19
Authors: Yuksel S.
Demirkan N.C.
Comut E.
Yilmaz M.
Gurses D.
Keywords: COVID-19
histopathology
microscopy
MIS-C
skin rash
albumin
anakinra
C reactive protein
fibrinogen
immunoglobulin
steroid
adolescent
Article
child
clinical article
clinical feature
coronavirus disease 2019
disease severity
female
herpes simplex
herpes zoster
histopathology
human
human tissue
incidence
keratinocyte
lymphocyte count
maculopapular rash
male
medical history
microscopy
myocarditis
necrosis
pediatric multisystem inflammatory syndrome
rash
risk factor
skin biopsy
biopsy
complication
immunology
pathology
preschool child
prospective study
rash
skin
systemic inflammatory response syndrome
virology
Adolescent
Biopsy
Child
Child, Preschool
COVID-19
Exanthema
Female
Humans
Male
Prospective Studies
Skin
Systemic Inflammatory Response Syndrome
Publisher: Lippincott Williams and Wilkins
Abstract: Introduction:A new entity, which occurs a few weeks after SARS-CoV-2 infection and resembling incomplete Kawasaki disease or toxic shock syndrome, has been defined and named multisystem inflammatory syndrome (MIS-C) associated with COVID-19 in children. The aim of our study was to describe histopathological characteristics of skin lesions of MIS-C patients to reveal whether there is a relationship between histopathological features and clinical manifestations.Materials and Methods:Seventeen who had skin involvement of 57 patients who were diagnosed with MIS-C between December 2020 and February 2021 were included in this prospective study. Demographic information, laboratory findings, and patients' managements were recorded. Skin biopsies were taken simultaneously of each patient. Formalin-fixed, paraffin-embedded skin samples were examined microscopically.Results:The rate of skin rash was 30% in patients with MIS-C and was predominantly the maculopapular type. The anatomical distribution of the rash was evaluated as localized in 10 and generalized in 7 patients. In patients with myocarditis, C-reactive protein and fibrinogen were found to be significantly higher, and lymphocyte and albumin values were found to be low. Herpes-like inclusions were found in the microscopic examination of 2 patients with a history of zona zoster in themselves or in their mother. There was a significant difference between keratinocyte necrosis and some clinical parameters.Discussion:Localized skin lesions appear to be associated with a more severe inflammatory. © 2021 Wolters Kluwer Health, Inc. All rights reserved.
URI: https://doi.org/10.1097/DAD.0000000000002091
https://hdl.handle.net/11499/47559
ISSN: 0193-1091
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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