Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/47559
Title: | Histopathological and Clinical Analysis of Skin Rashes in Children with Multisystem Inflammatory Syndrome Associated with COVID-19 | Authors: | Yuksel S. Demirkan N.C. Comut E. Yilmaz M. Gurses D. |
Keywords: | COVID-19 histopathology microscopy MIS-C skin rash albumin anakinra C reactive protein fibrinogen immunoglobulin steroid adolescent Article child clinical article clinical feature coronavirus disease 2019 disease severity female herpes simplex herpes zoster histopathology human human tissue incidence keratinocyte lymphocyte count maculopapular rash male medical history microscopy myocarditis necrosis pediatric multisystem inflammatory syndrome rash risk factor skin biopsy biopsy complication immunology pathology preschool child prospective study rash skin systemic inflammatory response syndrome virology Adolescent Biopsy Child Child, Preschool COVID-19 Exanthema Female Humans Male Prospective Studies Skin Systemic Inflammatory Response Syndrome |
Publisher: | Lippincott Williams and Wilkins | Abstract: | Introduction:A new entity, which occurs a few weeks after SARS-CoV-2 infection and resembling incomplete Kawasaki disease or toxic shock syndrome, has been defined and named multisystem inflammatory syndrome (MIS-C) associated with COVID-19 in children. The aim of our study was to describe histopathological characteristics of skin lesions of MIS-C patients to reveal whether there is a relationship between histopathological features and clinical manifestations.Materials and Methods:Seventeen who had skin involvement of 57 patients who were diagnosed with MIS-C between December 2020 and February 2021 were included in this prospective study. Demographic information, laboratory findings, and patients' managements were recorded. Skin biopsies were taken simultaneously of each patient. Formalin-fixed, paraffin-embedded skin samples were examined microscopically.Results:The rate of skin rash was 30% in patients with MIS-C and was predominantly the maculopapular type. The anatomical distribution of the rash was evaluated as localized in 10 and generalized in 7 patients. In patients with myocarditis, C-reactive protein and fibrinogen were found to be significantly higher, and lymphocyte and albumin values were found to be low. Herpes-like inclusions were found in the microscopic examination of 2 patients with a history of zona zoster in themselves or in their mother. There was a significant difference between keratinocyte necrosis and some clinical parameters.Discussion:Localized skin lesions appear to be associated with a more severe inflammatory. © 2021 Wolters Kluwer Health, Inc. All rights reserved. | URI: | https://doi.org/10.1097/DAD.0000000000002091 https://hdl.handle.net/11499/47559 |
ISSN: | 0193-1091 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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