Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47565
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dc.contributor.authorAcikgoz, Ozgur-
dc.contributor.authorCakan, Burcin-
dc.contributor.authorDemir, Tarik-
dc.contributor.authorBilici, Ahmet-
dc.contributor.authorOven, Bala Basak-
dc.contributor.authorHamdard, Jamshid-
dc.contributor.authorYildiz, Ozcan-
dc.date.accessioned2023-01-09T21:29:16Z-
dc.date.available2023-01-09T21:29:16Z-
dc.date.issued2021-
dc.identifier.issn0025-7974-
dc.identifier.issn1536-5964-
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000027712-
dc.descriptionJamshid/0000-0002-5823-1704en_US
dc.description.abstractThe aim of this study was to investigate the predictive and prognostic value of PLR, and the relationship between PLR and tumor localization. A total of 229 patients with de-novo metastatic CRC were retrospectively analyzed. The cutoff value for PLR was defined by the receiver operating characteristic (ROC) curve analysis and threshold value of 196.5 as best cut-off value was found. The higher rate of BRAF mutation was significantly detected for patients with PLRhigh (> 196.5) compared to those with PLRlow (<= 196.5) (P = .001). PLR was significantly higher in tumors located on the right colon (P = .012). PLR, tumor localization, the presence of surgery for primary tumor, the presence of curative surgery, the presence of metastasectomy for progression-free survival (PFS) and PLR, gender, BRAF mutation, tumor localization, the presence of surgery for primary tumor, the presence of metastasectomy for overall survival (OS) were found to be prognostic factors by univariate analysis. Multivariate analysis showed that PLR, the presence of curative surgery and the presence of metastasectomy for both PFS and OS were found to be independent prognostic factors. Moreover, a logistic regression analysis indicated that PLR and tumor localization were found to be an independent factors for predicting response to systemic treatment (P P = .023 respectively). Our results showed that pretreatment PLR was readily feasible and simple biomarker predicting response to treatment and survival, in addition it was significantly associated with tumor localization.en_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetastatic Colorectal Canceren_US
dc.subjectPlatelet-To-Lymphocyte Ratioen_US
dc.subjectPrognostic Factoren_US
dc.subjectSurvivalen_US
dc.subjectTreatment Responseen_US
dc.titlePlatelet To Lymphocyte Ratio Is Associated With Tumor Localization and Outcomes in Metastatic Colorectal Canceren_US
dc.typeArticleen_US
dc.identifier.volume100en_US
dc.identifier.issue44en_US
dc.departmentPamukkale Universityen_US
dc.authoridJamshid/0000-0002-5823-1704-
dc.identifier.doi10.1097/MD.0000000000027712-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorwosidHamdard, Jamshid/Mhr-4224-2025-
dc.identifier.pmid34871263en_US
dc.identifier.pmid34871263-
dc.identifier.scopus2-s2.0-85121464266en_US
dc.identifier.scopus2-s2.0-85121464266-
dc.identifier.wosWOS:000727992700052-
dc.identifier.scopusqualityQ2-
dc.description.woscitationindexScience Citation Index Expanded-
dc.identifier.wosqualityQ3-
item.languageiso639-1en-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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