Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/47565
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Acikgoz, Ozgur | - |
dc.contributor.author | Cakan, Burcin | - |
dc.contributor.author | Demir, Tarik | - |
dc.contributor.author | Bilici, Ahmet | - |
dc.contributor.author | Oven, Bala Basak | - |
dc.contributor.author | Hamdard, Jamshid | - |
dc.contributor.author | Yildiz, Ozcan | - |
dc.date.accessioned | 2023-01-09T21:29:16Z | - |
dc.date.available | 2023-01-09T21:29:16Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://doi.org/10.1097/MD.0000000000027712 | - |
dc.description | Jamshid/0000-0002-5823-1704 | en_US |
dc.description.abstract | The aim of this study was to investigate the predictive and prognostic value of PLR, and the relationship between PLR and tumor localization. A total of 229 patients with de-novo metastatic CRC were retrospectively analyzed. The cutoff value for PLR was defined by the receiver operating characteristic (ROC) curve analysis and threshold value of 196.5 as best cut-off value was found. The higher rate of BRAF mutation was significantly detected for patients with PLRhigh (> 196.5) compared to those with PLRlow (<= 196.5) (P = .001). PLR was significantly higher in tumors located on the right colon (P = .012). PLR, tumor localization, the presence of surgery for primary tumor, the presence of curative surgery, the presence of metastasectomy for progression-free survival (PFS) and PLR, gender, BRAF mutation, tumor localization, the presence of surgery for primary tumor, the presence of metastasectomy for overall survival (OS) were found to be prognostic factors by univariate analysis. Multivariate analysis showed that PLR, the presence of curative surgery and the presence of metastasectomy for both PFS and OS were found to be independent prognostic factors. Moreover, a logistic regression analysis indicated that PLR and tumor localization were found to be an independent factors for predicting response to systemic treatment (P P = .023 respectively). Our results showed that pretreatment PLR was readily feasible and simple biomarker predicting response to treatment and survival, in addition it was significantly associated with tumor localization. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Metastatic Colorectal Cancer | en_US |
dc.subject | Platelet-To-Lymphocyte Ratio | en_US |
dc.subject | Prognostic Factor | en_US |
dc.subject | Survival | en_US |
dc.subject | Treatment Response | en_US |
dc.title | Platelet To Lymphocyte Ratio Is Associated With Tumor Localization and Outcomes in Metastatic Colorectal Cancer | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 100 | en_US |
dc.identifier.issue | 44 | en_US |
dc.department | Pamukkale University | en_US |
dc.authorid | Jamshid/0000-0002-5823-1704 | - |
dc.identifier.doi | 10.1097/MD.0000000000027712 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Hamdard, Jamshid/Mhr-4224-2025 | - |
dc.identifier.pmid | 34871263 | en_US |
dc.identifier.pmid | 34871263 | - |
dc.identifier.scopus | 2-s2.0-85121464266 | en_US |
dc.identifier.scopus | 2-s2.0-85121464266 | - |
dc.identifier.wos | WOS:000727992700052 | - |
dc.identifier.scopusquality | Q2 | - |
dc.description.woscitationindex | Science Citation Index Expanded | - |
dc.identifier.wosquality | Q3 | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
1-s2.0-S0923753419577973-main.pdf | 54.54 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
10
checked on Jan 4, 2025
WEB OF SCIENCETM
Citations
12
checked on Mar 31, 2025
Page view(s)
84
checked on Feb 8, 2025
Download(s)
32
checked on Feb 8, 2025
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.