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https://hdl.handle.net/11499/47600
Title: | Favourable effect of ?-glucan treatment against cisplatin-induced reproductive system damage in male rats | Authors: | Kaya K. Ciftci O. Aydın M. Cetin A. Basak N. |
Keywords: | cisplatin oxidative stress spermiotoxicity testicular damage ?-glucan beta glucan catalase cisplatin glutathione glutathione peroxidase imuneks reactive oxygen metabolite superoxide dismutase antineoplastic agent antioxidant beta glucan cisplatin thiobarbituric acid reactive substance adult animal cell animal experiment animal model animal tissue Article controlled study drug effect enzyme activity epididymis histology histopathology lipid peroxidation male male genital system disease nonhuman organ weight oxidative stress rat reproductive toxicity spermatozoon density spermatozoon motility testis tissue treatment duration animal disease model human metabolism pathology spermatozoon count Sprague Dawley rat testis testis disease Animals Antineoplastic Agents Antioxidants beta-Glucans Cisplatin Disease Models, Animal Epididymis Humans Lipid Peroxidation Male Oxidative Stress Rats Rats, Sprague-Dawley Sperm Count Sperm Motility Testicular Diseases Testis Thiobarbituric Acid Reactive Substances |
Publisher: | John Wiley and Sons Inc | Abstract: | The aim of this study was to investigate the potential beneficial effects of ?-glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty-eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal-sized groups: a control group, cisplatin group (7 mg/kg in a single-dose cisplatin administered intraperitoneally), ?-glucan group (?-glucan given at a dose of 50 mg kg?1 d?1 for 14 day) and a cisplatin plus ?-glucan group (cisplatin and ?-glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid-reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The ?-glucan treatment improved cisplatin-induced oxidative, histological and spermatological damage. This study revealed that ?-glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties. © 2019 Blackwell Verlag GmbH | URI: | https://doi.org/10.1111/and.13342 https://hdl.handle.net/11499/47600 |
ISSN: | 0303-4569 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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