Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47600
Title: Favourable effect of ?-glucan treatment against cisplatin-induced reproductive system damage in male rats
Authors: Kaya K.
Ciftci O.
Aydın M.
Cetin A.
Basak N.
Keywords: cisplatin
oxidative stress
spermiotoxicity
testicular damage
?-glucan
beta glucan
catalase
cisplatin
glutathione
glutathione peroxidase
imuneks
reactive oxygen metabolite
superoxide dismutase
antineoplastic agent
antioxidant
beta glucan
cisplatin
thiobarbituric acid reactive substance
adult
animal cell
animal experiment
animal model
animal tissue
Article
controlled study
drug effect
enzyme activity
epididymis
histology
histopathology
lipid peroxidation
male
male genital system disease
nonhuman
organ weight
oxidative stress
rat
reproductive toxicity
spermatozoon density
spermatozoon motility
testis tissue
treatment duration
animal
disease model
human
metabolism
pathology
spermatozoon count
Sprague Dawley rat
testis
testis disease
Animals
Antineoplastic Agents
Antioxidants
beta-Glucans
Cisplatin
Disease Models, Animal
Epididymis
Humans
Lipid Peroxidation
Male
Oxidative Stress
Rats
Rats, Sprague-Dawley
Sperm Count
Sperm Motility
Testicular Diseases
Testis
Thiobarbituric Acid Reactive Substances
Publisher: John Wiley and Sons Inc
Abstract: The aim of this study was to investigate the potential beneficial effects of ?-glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty-eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal-sized groups: a control group, cisplatin group (7 mg/kg in a single-dose cisplatin administered intraperitoneally), ?-glucan group (?-glucan given at a dose of 50 mg kg?1 d?1 for 14 day) and a cisplatin plus ?-glucan group (cisplatin and ?-glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid-reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The ?-glucan treatment improved cisplatin-induced oxidative, histological and spermatological damage. This study revealed that ?-glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties. © 2019 Blackwell Verlag GmbH
URI: https://doi.org/10.1111/and.13342
https://hdl.handle.net/11499/47600
ISSN: 0303-4569
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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