Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47617
Title: The effectiveness and safety of ibuprofen and acetylsalicylic acid in acute rheumatic fever
Authors: Yılmaz M.
Gürses D.
Tükenmez G.
Keywords: acetylsalicylic acid
acute rheumatic fever
ibuprofen
therapies
acetylsalicylic acid
ibuprofen
nonsteroid antiinflammatory agent
child
human
preschool child
rheumatic fever
treatment outcome
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Child
Child, Preschool
Humans
Ibuprofen
Rheumatic Fever
Treatment Outcome
Publisher: NLM (Medline)
Abstract: BACKGROUND: Acetylsalicylic acid (ASA) is a non-steroidal anti-inflammatory drug used in the treatment of acute rheumatic fever (ARF) and it can cause serious adverse effects. This study aimed to evaluate the clinical efficacy and side effects of ibuprofen in the treatment of ARF compared to the classic treatment, ASA. METHODS: Children who were hospitalized for the treatment of ARF with isolated arthritis and mild carditis between October 2015 and October 2018 and who received non-steroidal anti-inflammatory therapy were evaluated in the study. We compared the demographic data, clinical findings, efficacy, and side effects of the treatments of the children, who were divided into ASA and ibuprofen groups. RESULTS: Of the 38 patients included in the study, 21 were treated with ASA (ASA group), and 17 were given ibuprofen (IBU group). There was no difference between the groups regarding the length of hospital stay, total treatment time, time to resolution of clinical symptoms, and normalization of acute-phase reactants. Liver enzymes increased during treatment in 13 patients (62%) in the ASA group and three patients (18%) in the IBU group (P?=?0.009). In the ASA group, 69% of patients with increased liver enzymes were under 11?years of age during treatment. Clinical side effects were observed in three patients in the ASA group while none were observed in the IBU group. CONCLUSION: The results of this study suggest that ibuprofen can be a safe alternative in the treatment of ARF, especially in young children. Although ibuprofen can be a safe and effective alternative to ASA, studies including larger series are needed on this subject. © 2022 Japan Pediatric Society.
URI: https://doi.org/10.1111/ped.15133
https://hdl.handle.net/11499/47617
ISSN: 1442-200X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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